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                  <text>December 21, 1982
Dr. Warren Stern
Burroughs Wellcome Co.
Triangle Park, North Carolina 27709
Dear Warren,

It was a pleasure to discuss clinical problems with you in San Juan. I
enclose a number of recent reprints of our pharmaco—EEG studies, as examples of
the power of this methodology. The study of flutroline predicted the clinical profile
more accurately than preclinical studies; and it is my expectation that the same
will be true for our study of 6-azamianserin. The pharmacodynamic study of
brotizolam is a replication of Itil's findings, indicating the reliability of the
methods. And the study of aspirin is a tour de force which we undertook as a
challenge and which has turned out to be one of our most popular and controversial
studies.
As we discussed,

I

am in charge of a l5-bed acute admission and

treatment unit and the CPD affective disorders clinic at University Hospital. 1 am
interested in assaying new entities for their psychoactive properties. While it would
be interesting to do so after their pharmaco-EEG profiles have been explicated,
this is not a necessary step. I have facilities to assess entities in patients with
severe depressive disorders, manic states, and acute sch120phrenia.
I look forward to hearing from
you. Thank you for a pleasant breakfast,
and my best wishes for a successful 1983 !

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

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              <text>1976 </text>
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