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                  <text>May

7, 1965

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Mr. Milan Matejcek
Sandoz A.G.
CH—h002

Basel, Switzerland

VII"?

”9‘"

mu

«raw-w»,

Dear Milan,

For your examination of the EEG effects of ngptropic drugs,
you mmyujﬁgrto write to Per Mindus (Department of Neurophysiology,
Karolinska Institute, Stockholm). I understand he has some reports
on piracetam which are inconclusive.
My

best.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MFzsl

�WI
WHOM
1’

May

5, 1980

Mr. Milan Matejcek
Sandoz A.G.
CH-QOOZ

Basel. Switzerland

Dear Milan,
have never developed a special program of analysis for
'nootropic' drugs. In our work, we have taken compounds of different
structure, and sought to assess their EEG profiles against the known
active compounds for different mental conditions. In the absence of
any effective compounds for the alleviation of the memory changes seen
in the elderly, we have not been able to define a nootropic profile.
I have enclosed copies of our most recent reports, including the summary
We

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5

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111'

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prepared for the

1978 EEG

congress.

two occasions, we analyzed tapes prepared by others in their
study of supposed vasodilators. These reports were negative, but I enclose
copies of the data summary for your information. While these are unpublished, you may quote them if you wish as personal communications.
On

that the evidence presented so far,
for a definite profile for a nootropic class of drugs is unconvincing. I
have yet to see a definite report of either EEG or clinical activity for
piracetam, and the data for other such agenst is equally weak. In a
similar vein, we have been uanble to define activity for the fragments
of ACTH and it is unlikely that the slight behavioral effects will have
As

any

when

an opinion, I would say

clinical utility.

it is

Good luck

completed.
My

in your review. I look forward to reading a copy

best regards.

W
a
.

Sincerely yours,
Max

Fink,

M.D.

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