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                  <text>my”

u

vi,—

s,

mmwwrw-qryq

a-m

October 15 , 1979
Jerome Levine, M.D.
Chief, Psychopharmacology Research Branch
NIMH

--

-

Rockville, Maryland 20857
Dear

Jerry,

-Thank.you for the copy of "Coordinating Clinical Trials
in Psychopharmacology", which I was able to read this past week-end.
to the earlier guidelines which have been
It is an excellent addition
and
provides an enViable standard for
issued by the Institute,
it some
of the sponsors of our studies of
notified
have
future trials. I
and
am sure that they will find it
I
of
the
volume,
the publication

useful.

I also want to thank you for the assistance you have given
of Organon. He has accepted the responsibility for
of
guidelines for the clinical trials sponsored by that
developing a set
he
has
and
written
a number of recommendations which clearly
company,
NCDEU
these will be adopted by his masters
believe
I
standards.
meet
well
as world-wide (although they have some
0.8.
the
as
for studies in
in countries where the AMP system
the
with
coordinating
trials
problems
Dr. Hank van Riezen

is standard).

:

Our own

-

-.

.

laboratories continue to assess new drugs in
we have identified three new putative psychoactive

phase I trials, and
3770, is
drugs in the past 18 months which have much promise. One, Org EEG
and

active than mianserin and tields a similar
behavioral profile, promising to be even safer than mianserin in lack
frustrated by
of cardiotoxicity and anticholinergic effects. We have been 1980
studies
the
ACTH
and
that
optimistic
are
fragments,
the studies of
My book on
DGAVP)
he
rewarding.
and
(DTVE
will
tore
of other peptides
BCT (Cbnvulsive Therapy: Theory and Practice) has been well received and
the first reviews were most kind. It also receiVed.0he of the 1979 Anna
Monika Foundation awards, so I am rather pleased.
clearly

much more

Again; thank you for sending the Volume.

My

best regards.

Sincerely‘yours,

'

"‘I-vw-rc

Max

Fink,_M.D.

Professor of Psychiatry

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