http://exhibits.library.stonybrook.edu/mfp/files/original/e3ca86791844e5581d52d7484b7aa70a.pdf d303f7247c39a5abc72e39d71c661960 PDF Text Text m... V"...we: November 2, 1979 Peter T. Loosen, M.D. Dorothea Dix Hospital Raleigh, NC 27611 Dear Peter. Thank you for the two articles, on the oral treatment of depressed patients with 80 mg TRH and the review of peptide effects. I had seen the Karlberg et al article, but in light of our discussion, I should be disappointed and assume that the likelihood that TRH over three weeks would be significantly antidepressant. Yet, the many observations including the three patients who responded in this series, suggests that we may be close, as close as the early workers were with l-dopa in parkin- son patients. For the meanwhile, I have decided not to replicate the study; but rather to try with two of the newer peptides, DGAVP and des-Tyr-gammaendorphin, to assess their central (EEG) effects. My associate, Yiannis Papakostas has been carrying out stimulation tests and dexamethadone—cortisol tests in every one of our depressed patients, referred for drug therapy or BCT. So far, in the first 15 patients, he has found more consistent DM-cortisol abnormalities which resolve with treatment, than TRH-TSH but the latter do occur in about 1/3 the cases, and he is confirming the observations of TSH blunted response in some depressed. He is using our schizophrenic patients as controls, and we are particularly interested in the ECT group. TRH-TSH It was kind of you to think of me, and my thanks. Sincerely yours, Pink, M.D. Professor of Psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Loosen, Peter T. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-8-296 Date A point or period of time associated with an event in the lifecycle of the resource 1979 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence