http://exhibits.library.stonybrook.edu/mfp/files/original/fbf140746e55b1a2156bcdf50fc3f08c.pdf cffa51d34daeb806ae302986ce50bc13 PDF Text Text E’ ,7 wn , -~- —. - “er—w.“ v www.mm u.‘ ~ . u 77x- _,_, awe—mm , Wu-“'~"AV‘—W1m’ av ‘I'run‘rrr-w—Mc' 'Vw-v-mr'w.u-r“-u-.mmw “cw-«ww’ww‘ v. , mummy» Mm..." ”WWW". "HM", _-,, a—nwmw-eu-r-vmrv-“v—hw.’»-~» . __ . WM” November 3, 1979 E g g E Alan Frazer, Ph.D. Depression Research Unit Hospital Philadepphia, VA PA. Dear Alan, Thank you ; E ' ’ E n { E I i r for sending of beta-adrenergic receptors as a me your report on the subsensitivity test for antidepressant drug activity. report is quite interesting and well done, but like other such efforts,which seek a single test to define 'antidepressant' activity, seems to fail in not being inclusive. The problems with such efforts are many, but the principal one highlighted by this report is the expectation that a single system is involved in treatments as diverse as BCT, TCAD, MAOI, stimulants, etc., just because these various systems seem to be useful in relieving a single symptom. Is it not likely that the various 'depression' syndromes reflect different mechanills, just like fever and headache may reflect different underlying pathophysiologies The course, that mianserin did not fit within the model leads to the speculation that perhaps mianserin is not an antidepressant But, as you are well aware, it is also possible that the single system studied is not general enough to be related to the syndrome of depression. I am confident that mianserin is an antidepressant, not because of its clinical evidence, but because its EEG profile in man is so like amitryptiline, that it will have the same or similar effects on brain function, and in depressed patients, should have the same behavioral effects as seen fiith amitryptiline. To the extent that amitryptiline is "antidepressant', so is mianserin. Of I I b E ? liberty of sending your report to my studies, Dr. J. J. de Ridder of Gas, Holland, with a note that he may write to you if he wishes additional information. I would be grateful if you would oblige his inquiries, if any. I am taking the my mianserin collaborator in My regards. Sincerely yours, Fink, M.D. Professor of Psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Frazer, Alan Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-8-295 Date A point or period of time associated with an event in the lifecycle of the resource 1979 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence