http://exhibits.library.stonybrook.edu/mfp/files/original/85b74d4687352bd3b790bc4a56dd2a6a.pdf 6c351587bb117bd009d25e0e5ae8da5f PDF Text Text November 5, 1979 Dr. P. Tyrer Department of Psychiatry University of Southampton Southampton, 509 hPE Deer Drs. Tyrer, Steinberg and Watson, The report of the possible epileptOgenic effect of misnserin (Lancet, October 13, 1979) is for from compelling. You note that the patient. with a long history of recurrent depressive illness, received nitrezepam, lorszepsm, and misuserin on admission for "a further episode or depression precipitated by the death of her husband." Hitresepsm was stepped soon thereafter; and for six weeks she received lorszepem and misneerin. Three days before a seizure, she stopped her lorszepsm. You conclude that this episode suggests that misnserin may have epileptogenic features, and caution physicians in prescribing misnserin in patients with a history of seizures. Was the possibility of the seisure as secondary to the withdrawal of benzodissepines ruled out as an explanation for the seizure? If so, how? If she presumably had no history of seizures, how can one conclude that misnoerin should not be given to patients with a history of seizures? �Dr. P. Tyrer ‘ 2. Nov. 5, 1979 ' have examined the EEG effects of mienserin in volunteer subjects in patients.“ we have described systematic EEG effects, but these are unlike those usually seen with compounds inducing seizures. While such studies do not preclude seizure induction, the likelihood is remote, and we suggest the alternate explanation, of benzodiezepine We and withdrawal, as more likely. Sincerely yours, Fink, M.D. Professor of Psychiatry Mex “Fink, M., Irwin, Pi, Gastpar, M. and do Bidder, H.: EEG, Blood Level, and Behavioral effects of the Antidepressant Mienserin (Org GB 9h). Psychoghermacologggigg; 2h9—25h, 1977. Irwin, P. and Fink, M. EEG Study of Misuserin (GB 9h) in Depressed Patients. Brit. J. Clin. Phamacol. 2: (Suppl.): h38-h93, 1978. MF:bc � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Tyrer, P. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-8-292 Date A point or period of time associated with an event in the lifecycle of the resource 1979 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence