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                  <text>July 10.

1979

Dr. C. L. Faingold
P.O. Box 3926
Springfield, IL 62708
Dear Dr. Faingold,

for sending me a copy of your report on the
I found it interesting and
of
antihistamines.
action
therapeutic
when
me
studied
the effects of antireminded
I
that
helpful. It
induced
slow
in the EEG by induced
waves
the
on
cholinergic drugs
seizures (ECT), I found that a series of central anticholinergics
(atropine, diethazine, benactyzine, diethaidlsuld reduce slow wave
activity dramatically. At the time, Dias-Guerrero, Feinstein and
Thank you

Gottleib (Electroenceph. clin. Neurophysiol. §5299-306, 1956)
reported that diphenhydramine also reduced EEG slow wave activity
after ECT. We believed then that this effect was related to central
anticholinergic effects of diphenhydramine-- perhaps that was a
reasonable guess.

have not continued our studies of antihistaminics,
back
but may get
to it if terfenadine gets to the marketplace.
We

My

thanks again.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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