http://exhibits.library.stonybrook.edu/mfp/files/original/ebc4d9c11aa6ac6591dcd8aadbf71e8f.pdf e9bfa6d423d9ddc1f5d601e9f6e664e5 PDF Text Text ‘_ - - an...“ .. .mpwwvwnwv .7 .m.--‘—v. - Q 3W v—n ‘1 w.” .c April 11, 1978 . . urns-I'm)..- WW. Mr. G. S. Avery, Editor—in-Chief ADIS Auckland, New Zealand Dear Mr. Auery, The report on Minaserin written by Brogden, Heel, Speight is well done, and I find little to modify. There are some errors in citations which I can bring to your attention, but the sense of the text is consistent with my experience with mianserin. and Avery that could be modified has to do with the screen and how this led to the study of mianserin as a thymoleptic. EEG analysis as a basis for the classification of psychoactive drugs has a long history with some definitive studies in 1961 and 1963 published by myself and Itil. In the mid—1960's, we saw the possible usefulness of the classification in predicting the activity of new drugs and the first studies were done with such drugs as fenfluramine, cyclazocine and doxepin. In each instance, the EEG screen was a better predictor of the clinical activity of the compound than the animal pharmacology. This was particularly true for doxepin, whose pharmacology was scan as anxiolytic in the early studies. Our study found it antidepressant, and since then, this view has been confirmed. Based on these data, I recommended to Organon that new drugs be screened and in 1970 they sent a number of compounds to Itil and myself, than working in separate laboratories. He found mianserin to be active and its profile as a thymoleptic led to the subsequent development. Even after the EEG screen and clinical trials, the pharmacology failed to meet the accepted thymoleptic standards. The importance of-the EEG screen could be emphasized, because, as Dr. Itil noted in his 1972 paper, he 'discovered' its thymoleptic activity. One emphasis significance of the EEG As to the citation errors-~ I note that Fall et al are dated 1972 on page 6 and 1973 on page 7. 1973 is correct. The citation is lacking in the citation list. Also, there is a citation to Pink at al (1977) on page 6, which is lacking 6n the citation list. I enclose a cepy of the 1977 report for your reviewer to cite if he wishes. Thank you for the opportunity to review this article presents the data in a fashion similar to my view of it. Sincerely yours, Max Fink, M.D. Professor of Psychiatry which � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Avery. G. S. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-6-228 Date A point or period of time associated with an event in the lifecycle of the resource 1979 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence