http://exhibits.library.stonybrook.edu/mfp/files/original/0f9a099ac2d1860000435fdf62d5bd6b.pdf d668106225b52cc551e3832f11ac79b8 PDF Text Text March 29, 1979 Turan Itil, M.D. Research HZI Tarrytown, New York Dear Turan, I have had a chance to read the Final Report Task Force on with some attention to the details, and Bioavailability I am writing because I believe the report is less sanguine than need be with regard to the methods already available to us to assess bioavailability and pharmacodynamics of drugs. Specifically, the section 7.2.2 should be expanded in some way to reflect the state of knowledge presented at our sessions. You may recall that two methods were discussed at length as the changes in brain function induced by drugs whichreflecting crossed the brood-brain bustier barrier, that of pupillography and of quantitative electroencephalography. These methods provide valid end~points to the effects of drugs on the brain, and as quantitative as established biochemical methods in this are regard. of the by ACNPwFDA Would you consider amending the paragraph 7.2.2 the addition of the following: ". . . There is currently no recognized standard approach, although pharmacodynamic methods such as the quantitative EEG and pupillography, which are responsive to the effects of drugs which cross the blood-brain barrier, provide the most logical opportunity for such development." Quantitative EEG methods provide indices the assessment of benzodiazepines (diazepam, bromazepam),formianserin, doxephn, thiothixene, phenytoin, among others, in studies from my laboratory alone. Others have made similar contributions, and the negative statement of 7.2.2 ought to reflect this experience. My best regards. Sincerely yours, Max Fink, M.D. Professor of Psychiatry �Y'" m... wwwknm April Turan HZI Itil, Research 150 White Tarrytown, - 10 , 1978 M.D. l Plains Rdd New York Dear Turan, It nice seeing you again, and we did enjoy the visit with Ellen. I felt a bit better after the debacle in Ottawa since we did have the occasion to talk again. was I enclose the reprints from the recent work by Bolwig. It is the clearest data that ECT produces an increase in permeability of the blood—brain barrier, and is quite compelling. Maybe it could be used in the TR? problem. My best regards. Sincerely yours, Max Fink, M.D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Itil, Turan M. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-6-227 Date A point or period of time associated with an event in the lifecycle of the resource 1979 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence