http://exhibits.library.stonybrook.edu/mfp/files/original/2fd749a13918b934f4c874e91a94b62c.pdf 4a0026cd33ac7abcac0afc36eed2629a PDF Text Text ‘ Judith June 20, 1979 H. Quattlebaum President and Executive Director National Committee on the Treatment of Intractable Pain P.O. Box 3h571 Washington, D. C . 2003‘: Dear Mrs. Quattlebaum, My experience with Opioids in limited to experimental studies of.the central effects of heroin, methadone and levomethadyl. and their antagOnists, naloxone and cynlaaooine. These studies were done between 1966 and 1972, at the New York Medical College. Some reprints derived from these studies are attached. It is not clear to me how ; othese experiences, which are focussed on EEG, pupillary response, gheart rate, respiration and mood, would be helpful to your mission. In our experience, we did find that intravenous heroin could produce a seizure. This effeet'could be blocked by naloxone. We ‘also found_that tolerance to methadone and levomsthadyl developed rapidly (balk days), as did tolerance to the agonist (opioid) effects fiftcyclazocine. concluded that the narcotic antagonists could be a useful therapy'of opioid dependence, if drug delivery could be assured; but opme to no conclusions regarding the usefulness of heroin. 1; 1 § we I J], e. K." - ‘ As 1. Evidence of heroin 2. No effects. See reports. special knowledge. ‘3, h, 5. Not studied. 6. Hot as therapy; only as a "challenge" 7. Ho. __ ‘w. .:—‘/¢fy . to your specific questions; activity of antagonists. to determine �J. H. Quattlebenm 8. 2. June 20, 1979 I could testify to the experience noted in the references. Scheduling e drug is an aflminiatretive and political act, not medicel. Nothing in our experience would suggest that heroin is uniquely different from other opioide, except in rate of entry to the brain and in half-life. The present restrictions are not based on the pharmacology of heroin; but on political considerations. Similarly, the suggestions that heroin is a "uniquely" mofe effective analgesic than other opioids, is not clearly pfoven. 9. 10. No. Probably not. history, and my con experience from 1966—1967. You may wish to write also to Dr. John Kramer (University or California at Irvine) and Dr. Arthur Zeke (971 Madison Ave., N.£.I.). 11. who haVe Only by extensive experience and knowledge of the pharmacology and history of heroin use. I trust these reports ere of game help. Sincerely yours, Fink. M.D. Profeeeor of Peychiexry Mex MF:bo Att. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Quattlebaum, Judith H. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-6-193 Date A point or period of time associated with an event in the lifecycle of the resource 1979 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence