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                  <text>3/
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v

”we”.

November 20, 1978

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"I...”w—

M.A. Taylor, M.D.
Professor &amp; Chairman
Department of Psychiatry

Chicago Medical School

Illinois

Chicago,

Dear Mickey,

role as searcher for new compounds that any be
across the data file on an orally active testosterone.
Mindful of your findings at Metropolitan Hospital, I thought that there
were two bases for an interost~~ the possibility that the compound could
have antipaychotic activity in its own right (particularly in therapy
resistant psychotic patients), either alone or aynergiatically with
an antipaychotic drug: or, as the analog of the high dose eatrone
studies which have heen reported by Klaiber in Worcester State as
successful in therapy resistant depressed women.
In

useful, I

came

my

I would appreciate your reading the enclosed file. Are you
interested (or stimulated) to follow up your earlier findings at metropolitan
Hospital What do you think is the likelihood of success for the effects
of testosterone as a psychotropic agent ?
Y

I will file an IND and try to
for
the
compound.
profile
It should be possible to carry out
cIinical trials in psychotic patients under the some IND.
find uh

EEG

During the next few months

I received a few anxious calls from NY PI.
site visit on their large application to examine the
,’effecta of lactate on anxiety. From their questions (I have not seen
1the application) it sounded like they were replicating your earlier
A

few weeks ago,

.Ihey anticipated a

application

and study.

I

I've almost completed all my ECT assignments. The book is in
,preea. I hare had to defend the treatment for a number of books and
I'Journala, and almost see the end of the york It is time to get back to
'
science and maybe EEG. I am setting up some studies of GK 78 (de Wied'a
latest peptide gragment) but the possibility of a testosterone study
&amp;

intrigues

me

even more.

One last comment. You will probably hear that your assistant,
Almy had a rough time before the VA merit review board.
you plan
another application, why not send
to me before
goes to the committee ?
Come and visit when you are in Rev York.

it

it

If

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