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                  <text>M,

—,r.

“WW",

..

_...

war-w

June 6, 1978
Donald F. Klein, M. D.
York State Psychiatric
722 West 168 Street N
New York City

New

Dear Don,

w...,.,...e..

Wow,

Thank you

for the corrections of the Hillside data.

this juncture, I cannot recall for sure what the question was
to which the answer was incorrect, but I do recall the data, more
or less, as you note in your letter. Whatever the effects were,
and we were impressed with the antidepressant activity of
At

chlorpromazine plus procyclidine, the marketplace, and our own
we were not that impressed with
the effects. I think what I tried to say was that if antipsycotic
drugs are active as antidepressants they must do so on some subset

activities since, indicate that

if at all.

of patients,

As you note, our failure to find a difference between
imipramine and CPZ was interepreted as an antidepressant action for
CP!. I guess we would be more cautious about that interpretation

now.

In any case, I thank you. I do believe that on toxicity
alone, mianserin deserves a rapid and determined appraisal in this
country. If it is true that it is antidepressant and if its cardiac
and anticholinergic effects are indeed lower, we should use it in
preference to the present TCAD. Good luck in your study.

I

Awe,

——-v._v-",_,..‘m"--

Institute

am

commiteed to writing a summary for Psychopharm.
done.
30, so will send you a copy as soon as

it

Bulletin before June
especially

Take good care of Geeg Asnis. He may be a
nurture him.

if you

Sincerely yours,

”(w

i-

pawn-v,

‘I-v'lv!

cm-‘r‘rﬂlﬂ

w-

n-

1

wwuwvw

scientist yet,

Max

Fink,

M.D.

.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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