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Baron Shopsin, M.D.

Department of Psychiatry
York University College of Medicine

New

550

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First
York

Avenue

City 10016

Dear Berry,

Enclosed is a revised and up-dated version of my
oh the effects of ECT in mania.for your volume.
The citations and some parts of the text have been edited to reflect
the latest findings and discussions, both at the Task Force of the
APA and the NIMH conference.

contribution

last year.

I trust that this version
My

may

replace the one submitted

regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of PSychiatry

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July 11,

1977

Baron Shopsin, M.D.
New York University College of Medicine
550

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First

Avenue

York City

Dear Baron,

Enclosed is a revised draft of the paper, Mania and
Electrvseizure Therapy (EST). Please replace the one formerly

submitted by this

latest draft.

are principally on page 7 where I have
citation to a new, important paper on the subject
written by HuCabe and Norris which just appeared. Rather than
make the changes in the galley, I send this draft at this time.
added a

The changes

My

regards.
Sincerely yours,
Fink, M.D.
Professor of PSychiatry
Max

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April 21, 1977
Baron Shopsin, M.D.

Department of Psychiatry
York University College of Medicine

New

550

New

First

York

Avenue

City 10016

Dear Barry,

Enclosed

Electroseizure

is the draft of the report,

Therapy (EST)

Mania and

for inclusion in your forthcoming

volume niviewing the informiation regarding mania.

your comments.

I
My

trust it meets your standards. I

would appreciate

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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�depressed patients

Some

drugs do respond to EST.

who do

not respond to antidepressant

In a recent report, Glassman, Kantor and

Shostak (73) found that depressed patients with delusions were markedly

unresponsive to tricyclic drugs-—lO of 13 so treated failed.

re-treated with

EST,

sustained response to

EST.

were

EST

action of

EST

is often used to reduce excitement

its effects

found

greater

EST

nine of the ten failures had a dramatic-and

is also effective in the treatment of mania.

where

may be prompt and

lifesaving.

improvement in follow—up

compared to psychotherapy

of patients treated with

EST

for

controls.

manic

and

The

sedating

agitated states,

Ziskind §t_al, (18h)

patients treated with

McCabe (129) reviewed

the records

in l9h5 e 19h9 and found shorter hospitaliza—

tion, greater percent improvement,
than for controls.

these

When

better follow-up results for

and

EST

Kalinowsky (105), Epstein (53), and Bianchi and Chiari

(l9) found-the improvements rates for

EST

treated manic—depressive patients

to be equivalent in the depressed and the manic phases. ‘Ebaugh and
Johnson (h9) reported

100%

social recovery for five

manic

patients treated

with pentelenetetrazole; and Thorpe (171, 116) described the efficacy of
multiple daily treatments in acute mania. Comparisons of the clinical

efficacy of lithium
and

recurrent

mania

The

and EST, alone or combined,in the treatment of acute

are not available.

efficacy of seizure therapies in depressive illnesses

may

also be seen in clinical comparisons of different methods of inducing the

seizure. Studies

comparing EST using

unilateral or bilateral electrode

placements find the two methods effective in reducing symptoms and

shortening hospitalization (3,
29

studies in

which the

M3,

uh).

D'El ia and Raotma (hh) examined

results of unilateral electrode placements

were

�b»

i415

�De _F¢'r\ \C

Proposed Outline of Book Entitled:
A PROFILE IN PSYCHOBIOLOGICAL RESEARCH:

MANIC ILLNESS

Editor: Baron Shopsin, M.D.

\/

Preface - Introduction ------- §B. Shopsin, M.D.
What is Mania

5

—————————————

W

Wot-sen,

Ginsburg,

G.

Longitudinal Review Starting with the term "Folie Circulaire
by Bairget and Falret ------—) Kraepelin
----------of'9 Bipolar and unipolar illness
Description a dynamic or descriptive nature

/

before schizophrenia?

Analytic Concepts

Other

III

IV

Diagnostic Considerations: Clinical Aspects:
D.D. with schizo-affective illness
B. Shopsin, M. D.

E‘P'DEMIOLOﬁq

3—.

Blamm/
V

Epidemiology-mad Genetics—————— J. Mendlewicz

V‘

Neuropharmacology

VI\

Treatments
1.

Biological

Selzer, B. Shopsin andv
S. Gershon

-------------J.

&lt;
,

2 .

VIII

V

ECT - Max Fink

/

92*

Psychoactive Drugs - B. Sh0psin

Wm.

/

Other (e.g. analytic, behavioral, family therapy, etc.)
Ginsberg

Concluding Remarks

V

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