http://exhibits.library.stonybrook.edu/mfp/files/original/213f06b5e89372ee5cb1682a332821f2.pdf 0a7fb1db441c3f2bb45725295ffd1c43 PDF Text Text ' June 30, 1978 Gilbert Honigfeld, Sandoz, Inc . East Hanover, N.J. Dear Ph.D. 07936 Gil, In 1971, when I first became acquainted with the pre-clinical data on mianserin, I found that the first human trial had been done in volunteers, and as part of a Ph.D. thesis, a young investigator had used the OFF procedure and had found a marked decrement in fusion threshold with low doses of mianserin. It was 13% data, more than any animal data, which led to the EEG trials and the finding that mianserin did, indeed, have a specific EEG profile. The rest is history. Since 1973. I have included OFF data in every EEG study. So far, using rather simple procedures, we have been impressed that CF? rates change in a dosearelated manner whenever we are studying active compounds. The mianserin data was published in our pharmacodynamic report in Psychopharmacology (2&z2h9-25h, 1977). We use a simple monocular fusion procedure with three determinations of the ascending and the descending flicker threshold, averaging the results of the six trials. I was impressed with your elegant procedure and would like to replicate it. I am confident that active drugs will show their effects on the more sensitive procedures, like CFF, if they affect brain function. However, the determination can only be gross for classification purposes, since discrdminations are only possible in two directions. But as another index for pharmacodynamic studies, we have been impressed. The mianserin report is not yet does for NIMH. The data are derived largely from the 1977 meeting on mianserin held in Amsterdam in October and published as a supplement to Brit. J. Clin. Pharm., supplement 1 to volume 5. My regards. Sincerely yours, Fink, M.D. Professor of Psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Honigfeld, Gilbert Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-029-2-067 Date A point or period of time associated with an event in the lifecycle of the resource 1978 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence