http://exhibits.library.stonybrook.edu/mfp/files/original/031b2e211f0998ae3c1366c6e94d4504.pdf d68dc10b796e73eda940a5ba16cd5f08 PDF Text Text / *5/15" January 27, 1978 to: Dr. Al-Chalabi From: Max Subject: Attached Fink, H.D. 5 reports on clinical subjects. five reports you submitted are interesting what the immediate question may be, but I unclear It is assume you have two: are these items publishable, and are they a reasonable basis for clinical studies. Since they differ. very much, I shall try to discuss each one separately. Overall, the reports are interesting case records and reflect the variety of the experiences at L-u -- indeed the wealth of case material is documents. The astonishing. ' study of temporal lobe psychomotor epilepsy masquerading as psychosis is quite good. Two of the‘ cases are convincing; two are fragments. As a case report, the introduction is inadequate. The EEG records need samples and the report of a neurological expert. There is a special issue, however, which cannot be answered retrospectively: the patients were receiving antipaychotic medication at the time the EEG records were taken. These compounds were in doses high enough to alter the EEG. How are we to separate the EEG effects of drugs from the natural effects of disease ? A case report, to be publishable today, should be a clear example of the problem, and should enlighten the reader under what conditions he may hope to find the same problem. The discussion fails to do this~~ it should explicate the symptoms that alerted you, and should alert others, to the significance of the EEG and the diagnosis (and treatment) of epilepsy. B! The ' to your comment that few reports are in the recent literature—- probably so, but that may be because the syndrome has passed into the textbooks. I suggest you read the writings of Dania Hill, Ajmoneonarsan, Gibbs, Gastaut, to name a few who have described these syndromes. I would particularly urge you to look at Gastaut and the French literature, where this syndrome has been dissected As microspopically.. �Al'Chalabi .OOO‘UOOIODOOODOD January «. -- 2 2. The combination of lithium and a diuretic has been discussed at length recently by scientists at the University of Pittsburgh: Kupfer comes to mind. but there are others in the same laboratory. see Clinical Pharmacology 8 Therapeuticsg‘1976—77. 3. Low serum lithium. This is an interesting reason for low levels. It could be the basis for a letter to the editor in one of the journals. like the JANA or Lancet, when there is an article describing problems with lithium levels. If the author omits this reason, it would be useful to write then, explaining your epperience. that would make , . n. This report is unclear. I cannot find a it the basis for a study. theme 5. The issue of hypothyroidism in lithium therapy is well defined in the literaturen- as you have noted. While is clinically important, it is not clear what you propose to add to the solution of the problem. It is commundable that you should propose to assess thyroid function in the patients under your care and that such study will be to their benefit is net disputed. But what do you wish to do to add to our knowledge it w-m "N'Hw‘zv 27. 1978 psool‘obeoobsrojo‘ipage of the reports fame From this review, I am not optomistic that any is publishabls except the I trust these one noted in letter comments are of some help. ? � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. 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