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                  <text>m

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April 5, 1978

E

Margarito T. Hays, H.D.
Medical Research Service
Veterans Administration
Washington, D.C. 2ou20
Dear Dr. Hays,
work

of

I

am

pleased to respond to your invitation to assess the
is being considered for an appointment

Dr. Larry Squire, who

as a Research Career Scientist.

;

My association with Dr.
Squire began about four
ago when I noted his reports on the effects of BCT on memory.years
heard him speak at Rockefeller University and at the Winter I
for Brain Research, and then joined him on a panel on ECT at Conference
the Society
for Neuroscience. On each of these occasions, I learned much and
was
impressed with his knowledge of brain function and memory. When asked
fer recommendations for a panel being organized NIMH assess the
status of ECT, I recommended Larry and he becamebya paneltomember.
Later,
when asked to recommend a scientific
consultant to the Task Force on
Convulsive Therapy of the American Psychiatric Association, I
again
recommended Larry. In both positions I have worked
with
him, and shared
the task of assessing the effects of seizures on brain function.

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.
a:

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Dr. Squire was trained at H.I.T. with my former
teacher,
Hans Lukas Teuber —- a critical thinker and
I
teacher.
believe
Larry learned much there, and came away with a keen

Prof.

problem of memory,

its retention

interest in the

its loss. I think it is to his
studies
and

individual credit (since such
were not in Dr.
repertoire) that he saw the merit in examining memory Teuber's
and
amnesia in the one reversible paradigm in man which is functiond
ethical
to
examine, that of convulsive therapy where amnesia is a
regular
of the treatment. Further, since the amnesia is reversible, Dr. feature
quire
had the advantage of examining its development and
in the
its
recovery,
same patient, within a time span of weeks to months
-- surely finite
enough to be credible.
The techniques for the study of
function in ECT are
the standard psychological paradigms. Since memory
became interested in
Larry
the long term effects of BCT, he developed novel
of memory based
on TV exposure during different decades. His teststests novel
and
are
sensitive, and have become accepted not only in ECT research, but seemingly
in

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2.

studigs of

memory

in drug assessment and neurosurgical interventions.

While most of his emphasis in the past few years has been
in the EC? process, I think his interest is broader, in the memory
process itself. To this end, he has undertaken studies of amnesia
fellowing surgery, trauma, and in systematic studies in animal
experiments. His work has consistently been well designed, carefully
done, statistically sound, and with the most reasonable controls. His
evaluation of the differences between unilateral and bilateral ECT
are among the most compelling new data in this field, and his assessment was an important feature of the recommendation by the APA
Task Force that unilateral ECT be considered the primary mode of treatment in depressive illnesses.

I believe his work to be sound.

skill to deal

He

has shown the necessary

attracted bright young
clinicians,
researchers to his laboratory. My assessment is best expressed by
the fact that when the Long Island Research Institute, a research
arm of this Department of Psychiatry, was seeking young talent fer
its staff, I recommended him highly and sought him out. Unfortunathly,
Long Island did not seem as attractive as Southern California. Nevertheless, my offer remains.
with

and he has

His work at the APA TAsk Force and the NIHH evaluation
to have good political skills. His presentations were well
documented, and I have every reason to be pleased with my
show him

recommendations.

While he is young in years (37), his experience since his
doctorate (1968), and his record of publications and presentations
support the recommendation for his appointment as an Associate
Professor.

I

am

pleased to

recommend him

to you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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