http://exhibits.library.stonybrook.edu/mfp/files/original/ec9c73238944c07793ae69334178371a.pdf 248ac04bf179e217911dbbf76b7a05e7 PDF Text Text W? Hatem Al~Chalabi, M.D. June 12, 1977 Suffolfl Developmental Center Box 788 Melville, New York Dear Dr. Al—Chalabi, I have read your proposal, to study the effects of lithium therapy on aggressive, disruptive and self-mutilating behavior in patients with mental deficiency (severe). In the main, the intent is clear, the issues well thought out, the misSion important, and the safety well within the margins ordinarily set by our community. Indeed, I can find only two questions of merit. Selecting dosages of lithium that will yield plasma mBq/l is a goal that is set in the study. While these levels may be necessary, I think that the conservative approach within a new setting is to set a lower level as the goal, one within the therapeutic range, but surely not associated with side effects, such as 1.0 mBq/l. If there is no therapeutic efficacy or toxicity at these levels in 3 to 6 subjects, then the higher level can be set for the remainder of the sample. If you already have experience at these lower levels, then this conservative step may not be necessary. levels of 1.5 The second issue is that of consent. The protocol does not discuss this issue; one that is a problem since the population is made up of minors with mental deficiency. A consent form should be prepared for the relatives, describing the goal and methods of the study. These comments are my own. Should you wish to have hhe advice of the Research Committee of the Department of Psychiatry and the Long Island Research Institute, I would suggest you send a revised copy of the protocol, with your curriculum vitae and the consent form to the Chairman of the Department, Stanley Yolles, M. D., and he may refer it to the appropriate committee. Good luck in your study. Sincerely yours, Fink, M.D. Professor of Psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Al-Chalabi, Hatem Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-028-6-297 Date A point or period of time associated with an event in the lifecycle of the resource 1977 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence