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                  <text>/j

4v

/

August 17, 1977

Dear Mark,

I have not had much experience with drugs that inhibit
libido outside the ones described in the third page of the report.
I, too, have had patients with schizophrenia treated with antipsychotic
drugs who complained that they were less interested in going home than
we thought they should be. A discussion showed that impotence was a

factor.
In

my

I have had more experience with sexual stimulating drugs.
work with opiates (also sexual downers and heroin was regularly

associated with impotence), I used the narcotic antagonists cyclazocine
We found that patients on cyclazocine showed increased
libido, aggressiveness to nurses, and even priapism. We were not sure
at first whether it was a direct result of cyclazocine or the blocihde
of the negative effects of heroin. In an experiment in depressed patients,
cyclazocine also stimulated libido, but here, also, we could not be sure
it was a direct resuly of cyclazocine or a result of the relief of
depression. When we tried the effects of nalozdne, the findings were
never clear. These data were reported by Alfred Freedman about 1972—73.
and naloxone.

studies of chronic hashish users in Athens, of #7 long-term
insisted that hashish use improved libido, performance,
and potency. We checked with the wives, and in social worker interviews,
2/3 favored intercourse with their husbands on hashish Again, we could
not be sure it was a direct effect of hashish or the absence of the
users,

In

my

more than 2/3

irritability these

men showed during withdrawal from hashish. The data
: Hashihh— Studies of Long—Term Use, edited
R. Dornbush and M. Fink, Raven Press, New York, 1977.

can be found in the volume

by C.

Stefanie,

I trust these

comments

are helpful.
Sincerely yours,
Max

Fink,

H.D.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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