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                  <text>w.
John C. Kramer, H.D.

August 22, 1977

University of California

Irvine, California

Dear John,
NIMH

I will continue to be optimistic that the funding from
will yet come through; but will answer your inquiry in the

meantime.

The book on

the Greek study

was

published in July and

should be available within the next few weeks. In it, as in the
prior Jamaica study, and the one from Costa Rica to follow, there
is little evidence that chronic hashish (ganja) smoking has any long—
term effects. These observations are in direct contrast to the
earlier literature, particularly from India and Egypt; and the more

recent reports from these countries by Souief and Chopra. Their
latest data may be found in the 1976 conference proceedings (New
York Academy of Sciences, vol 282, edited by Dornbush, Freedman and
Fink) where these authors cite large numbers of psychotic cases
which they ascribe to hashish use. Not only do they cite evidence
for psychosis, but criminality (other than possession of hashish)
as well. Chopra does not limit his findings to patients in hospitals
in India: he says that in interviews with drug users (site ?) he
made the observations. Souief worked in prisons, so his population
also is not a hospitalized one.
I would resphrase the question: Considering the differences
in incidence of behavioral abnormality, including psychmsis, reported
from India and Egypt compared to the studies in Jamaica, Greece, and
Costa Rica, could the findings reflect differences in material smoked;
in the observer ratings; in the sample populations selected for study;
or in the standards used for diagnosis ? If one were to start in
India, it would be important to visit Chopra and assess his populations,
his methods of assessment, and the material his subjects smoked first. If
some differences between the studies emerged from these observations,
they can be verified in subsequent studies.

If hospitalized patients are the focus of study, one could
with Frank Knight in Jamaica. In the Same NY Ac Sci volume, he
has a report, mostly anecdotal, but well written that there is a
defined incidence of psychosis due to ganja. In Athens, Miras was
still convinced that this was true, but when a Greek team visited
the major mental hospital, they were unable to verify a cannabis psychosis
syndrome in the patients hospitalized for a long time. Perhaps the same
start

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Kramer, John

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August 22, 1977

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page

in Athens could be done in Jamaica. There
advantage of language~~ they speak English.

re-assessment

made

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is the

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for anthropological and sociological studies is
did not answer these questions at all, partly because we
great.
wished to focus on the findings reported by Hires, that most of
his users had brain damage. But the more interesting question
emerged in our study, as in others: why do cannabis users continue
to use the drug ?
The need

We

There are many

first steps--

one

is outlined in

your

letter.

is to call or visit Steve Szara and get a picture of the
present studies in progress, and the possibility of undertaking such
a study in India. I would also suggest that you write to Dr. Chopra
after reading his report and asking whether he would cooperate in
other studies. Perhaps someone from NIDA is already there. If not,
and Chopra is willing, I think it should then be possible to formulate
Another,

a proposal based on his observations (much as we did with Miras'
observations) with the additional data from Szara (and perhaps

Petersen). Finally, you would do well to visit a number of
the others still interested in this question, to get an idea of
what the present thinking of the chronic cannabis syndrome is:
Sidney Cohen, Vera Rubin, Henry Brill come to mind.
Bob

r
.r-

-&lt;.

From my awareness of the issues, the NY Ac Sci volume
provides the basis for the questions to be answered. The Greek, Jamaica,
and Costa Rica studies are internally consistent in major matters——
only the Indian and Egyptian data are incongruous and I think that
this is the area of study now.

vw,‘-—r‘.-'Hw.fyr

I said in Irvine, I would be pleased to help you develop
such a study, and when the time comes to negotiate with NIDA or other
As

agencies for support, I have

some experience wﬁgich may be helpful.
will need a social-anthropologist or anthropo-sociologist in
addition to your psychiatric background. If you need a psychologist,
and I think you will, then one aware of cultural differences in
testing would be the one to identify.

You
.:

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Separately, I am sending you a copy of the
I think the questions come from it's papers.
My

NY

Ac

Sci volume.

best regards.
Sincerely yours,

cur—or.“

.

-

vacuitwn'ﬂrnrxx

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‘

Max

Pink, M.D.

Professor of Psychiatry

.

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