http://exhibits.library.stonybrook.edu/mfp/files/original/3cb3a4826ce3252b85df2aef83fc2d90.pdf 01a74ee3b77b5d313aa7683d90d6da33 PDF Text Text x law a» 40"me :nnsvznr w—r ~, Inna-w- wy... ‘I'“(“'. w“.- ._,..,.,,W.,~r. vlvu/anH. -., ‘nflV‘Lvr‘r'vvv ”H... a. , , . . .,, .,_.,,.,....~a. n.— .mmw—l-w n», _. 3;. :‘x-i '1'.“er {mtgyr‘rw'v r.7v..lr'-"t:\1vw. w. April ll, v'ufirh‘avv‘n""!v~n'v~m: nay-aw ,- . - « , . 1977 Dr. Francis C. Colpaert Jannsen Pharmaceutica Beerse, Belgium B-23H0 Dear Dr. Colpaert, It has been a number of years since I was directly involved in studies of narcotics and narcotic antagonists, so that your questions came as somewhat of a surprise. Nevertheless, I shall try to answer as best as I can. subjects repeated doses of heroin that we did not observe tolerance. When we gave oral doses of methadone, tolerance developed rapidly, and when we gave such subjects injections of heroin, we were able to observe cross—tolerance. Depending on time after oral dose of methadone and dine, subjects either could or could not distinguish placebo from heroin. They generally used as cues their subjective feelings of relaxation ("high") plus the change in skin tingling, respiratory slowing and occasionally the relief of irritability. When we gave patients levomethadyl, they developed tolerance as they ddd to methadone, and the same pattern of cross tolerance to heroin, with a different time course. When patients who are tolerant are given a single dose of naloxone or cyclazocine, a severe withdrawal syndrome is precipitated. These are the types of experiments we carried out, and based on these observations I would think the answers to your questions are as When we gave intravenously, the timing was so spaced follows. 1. The discimination of a narcotic from a placebo is dependent on dose of the narcotic, state of the subject (tolerant or 'clean’), and time in the withdrawal period that the narcotic is given. If repeated administration is rapid (doses within a few hours of each other, as in three or four times a day) then tolerance is seen easily. 2. Users discriminate active from inactibe material their central effects mainly: relaxation, euphoria, drowsiness, decreased irritability; and to a lesser extent from peripheral cues. from also use the relief of withdrawal symptoms allowed to devlop. They if these have been m - t.» H" -w- w; .— mn. v. ~ _..-- �q; (an. - -Wm—_~< - Dr. colpaert 0000000000000mch11’1977 000.000.000.000 page2 to tolerance. 3. The euphoric I trust these effects of opiates are subject comments are helpful. Some years ago, 1970 or 1988, I visited Beerse seeking some undeveloped narcotic antagonists as werwere then hoping to find an improvement on cyclazocine. I remember with pleasure the cooperation of the laboratory personnel, and I am pleased that your work has continued. My work at the New York Medical College continues under the leadership of the chairman of the Department, Professor Alfred M. Freedman. Should you wish some additional information regarding their recent experience with heroin, naltrexone, etc. you may wish to write to him. Sincerely yours, Max Fink, M.D. Professor of Psychiatry � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Colpaert, Francis C. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-028-5-239 Date A point or period of time associated with an event in the lifecycle of the resource 1977 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence