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                  <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

4/,

5

I)cpurnncntofPsychhnryinuchhavknalSdencc
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phonc25164®hL2447

.

.

April 27,

1977

Committee on Awards, Grants in Aid of Research
Sigma Xi National Headquarters
345 Whitney Avenue

New

Haven, Connecticut, 065ll

Gentlemen:

like to endorse the application of Mr. Jay Schneider
of the effects of ACTH 4—10 on the EEG and DC
recording characteristics in monkeys. I have known Mr. Schneider for
half a year, as he has been associated with Dr. John Stamm and Mr.
Oliver Gillespie in their studies of ACTH H-lO.
Mr. Schneider will graduate from the State University of New
York at Stony Brook in June, and is matriculated as a graduate student
in psychology at this University for September, 1977. During the past
year he has been an active collaborator in the studies of ACTH #10 and
he proposes to continue these studies next year.
His interest in the problem has been stimulated by Mr. Gillespie,
his
by
rand
readings. I have been a consultant to the project and in the
late fall, I invited Dr. Henk van Riezen of Oss, Holland to visit the
project at the University. The meeting was fruitful fOr it clarified the
direction of the research and the present work is an outgrowth of that
I should

for support of

.

session.

a study

'

studies of the effects of peptides on memory and brain
functions are derived from the work of David de Wied of the University
of Utrecht. I have been doing some of the human assays in my laboratory
and stimulated the present efforts by Stamm and his colleagues. The
significance of the work is well defined: the effects of ACTH 4—10 seem
to prevent the extinction of a learned response. It provides an interesting
opportunity for clinical studies in patients with memory deficits due to
aging and as a result of electroconvulsive therapy. We are pursuing both
leads clinically. The work proposed here should provide a neurophysiologic
underpinning for the clinical studies.
Mr. Schneider is working in a well equipped laboratory under
experienced and competent direction. The funds requested will permit the
present efforts to continue; to expand the measurements of changes
induced in the EEG and in DC recordings from brain areas not studied
well before, the prefrontal and infratemporal cortex. In the rapidly
expanding field of peptide studies, I think that these exercises at this
University will be most.helpful in understanding the effects of these
substances on brain functions.
The

Sincerely yours,

7L.»

Max

J’W

Fink,

M.D.

Professor of Psychiatry

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