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                  <text>March 10, 1976

Dr. Lannnrt Klaus

KunsshﬁsIVngn 9
I~260 lh GlumslSv
Sweden

Dear Dr. Klaus,
and

Your

letter of

Just forwarded

to

me

23 Dooembur VI! sent

to

my

former University,

- I regret tho delay in replying.

Following our work on oyelazocine and naloxone, as referred
the U.8. Government actively supported the developmznt of
1971,
in
to
new
antagonist, noltrexnno. This ﬁrm; ho: had uxtonsivo clinical
a
antagonists. Clinical trials
triols, and now seen: superior to earlier
and
the
drug is not yet marketed.
under
auxpioos,
research
are still

laboratories which tested the antagonists found their
difficult. When patients have the choice between methadone or
naltrcxonc. thqy surely prefer mathadone. I bolieve that in N.Y., only
my {armor co~worker. Dr. Riohard Rounick in actively using naltrexone.
He reports good clinical results.
I do not believe thot nnltrexone will be very successful,
especially when it oontinuon to compote with nothadono.
use too

Most

Thank you

for your inquiry.
Binoerely yours,
Max

Fink,

M.D.

Profelsor of Psychiatry

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