http://exhibits.library.stonybrook.edu/mfp/files/original/123085fa7f102b9a559762f7b5abf4d5.pdf c76d0a843fd4699ef3382af5849a6e11 PDF Text Text MW~ ~ w—"q—w—gw -»-. rw-vww "vu __.‘. . "gm-"w .1» w. k August ’4. 1975 Ms. Maya Pinea‘ h72h 32nd Street, washington, N. w. 20008 Pines, Dear Ms. m. D. C. for alerting me to the latest issue of Saturday to the fine article that you wrote. It does capture the excitement of our work. ORG 2766, the long acting peptide. will be in clinical trial in Europe and the U. 8. this winter. It is going through human toxicology trials now. Among the early tests in the U. S. will be assays of its effects on the EEG and on memory function, and in elderly patients. The studies of ACTH h~hlfin the elderly are in progress now at New York Medical College and Néw York University, and soon will also boast the Hillside Hospital in New York. and Thank you Your article was well written and described the state of the you.may wish art well. Perhaps, among your other writing assignments, to tackle another interesting story. The human EEG has been studied since its first published report by Hans Berger in 1929. During these hs years, there have been many applications, including some of those described in the Saturdgy Review. One interesting development which is not widely known is the use of EEG methods to find new drugs for clinical psychiatry. Since the first descriptions of modern psychoactive drugs in the early 1950's, most cons pounds developed by industry are based on their similarity to an ettablished compound, or to their effects on animal assay systems. The first methods produce "me, too" drugs; the latter are often inaccurate, for someilIuInnds that are psychoactive do not satisfy the animal assay ‘ criteria, useless. and some compounds that meet assay requirements are clinically quantitative EEG analysis has been successful in providing a classification of psychoactive drugs that is based on neurophysiologic, The not on chemical criteria; and new psychoactive compounds have been found by these methods. �‘V’nwr wuss-r: r‘wr‘l-YW' V 7.77 ._ .. nu war WWW‘IC'W‘wummmw—VVnruwman-rm—w "1. war "W"‘m‘ -wn.w.~A—a-.r-a—mm.w~rnrw—qw—~nwr-sm—r—mvw M's. Maya , g i - rmr-~ 4 —:.-, W; cm. y!"7!f‘l‘7"*‘ . qmiuvw-prw—u.— -—.-1-.- wmawW..—V.w-ywu-.m Slit/75 -* EEG methods hare also been extended to estimates of the half bioavailability of drugs. This latter use has become important as the FDA has demanded that drugs from different manufacturers meet stringent standards of safety, purity, and availability to the patient. These studies show an intimate relation between changes in brain function and behavior in man. Some physiologists describe the electrical activity of the brain as a 'matabolite' of brain function, reflecting its underlying activityh. The quantitative analysis of EEG is distinctly different from the clinical analysis of EEG.as is ordinarily done by neurologists. It depends on careful control of the setting of the experiment, and measure— ments or the EEG, using digital computer analytic methods. A review of these developments would be timely, for it will provide the lay reader life E Pines m—N and with another View of brain function to complenont his information of depth electrodes, chemtrodca, biofeedback, and sleep research. - . I am enclosing two reprints describing this work, one for that may give you a better idea of this topic. 1969, and one for l97h, Again, have an opportunity congratulatiOns on a fine report. Perhaps to meet'to discuss this interesting project. my we Sincerely yours, Fink, M. D. Professor of Psychiatry Max MF/mr Enos. will , 7 Wm, e..- um v.7. V...”— __ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Pines, Maya Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-028-2-129 Date A point or period of time associated with an event in the lifecycle of the resource 1975 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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