http://exhibits.library.stonybrook.edu/mfp/files/original/f2d196e76048989d928f79de74f691cd.pdf d1df7d16564c6565d6afb02d07e1ce11 PDF Text Text “ v~w~:,-, ."‘<-'wru‘e' February 6, 1985 Mr. MoQuade, W. Fortune Magazine Senior Editor 1271 Avenue of Americas York, New York New Dear Mr. Mchade: this The death by suicide of Mr. Black of United Brands earlier it ill, week set me to wondering whether he had been depressed; he had he had sought treatment; and then, to musing that even he would have received the was unlikely that seen a psychiatrist, treatment most effective for depression ~ convulsive therapy - because as? the many professional and lay misconceptions of this treatment. . if it it Among reasons for its.lack of use are misconceptions about mental name, 'shock therapy' , and the bade press, devastating article published by the New Ibrksr this illness, the{fond-we exemplilied y a summer. Perhaps this is the time for Eortune, as a follow—up of the article on psychiatry. to assess some of the recent data on depression -— its genetic components. relations to alcoholism, modification by drugs. maintenance therapies, and the role’of’nechanism of action of convulsive therapies. ' Should there be a story here, I would be glad to get you or one of your writers started. It has been a subject of research interest for me since 1952, and I can provide the relevant literature and contacts. However, there is another story of more direct interest to the readers of Fortune. particularly those involved with drug development that could be examined. For two decades, I and others have quantitatively measured the electrical activity of the brain the EEG), and used these methods to predict the clinical application of new drugs in the treatment of the mentally ill. These methods are based on digital computer analytic methods (we use IBM, others use DEC equipment). They have been developed so that specific applications are now being made. �Most of the established psychotropic drugs have been classified into nine major classes, based not on their chemical structure, but on their EEG effects in man. Using this classification, putative psychoactive compounds have been examined and for a number, where their EEG classification clearly fit one of the pigeonholes, a prediction has been made for their clinical application. These methods have been successful in defining clinical uses for doxepin, cyclazocine, mianserin, cyproheptadine, and a number of other numbered compounds. The technic has also been applied to definfiki bioavail— and neurophysiologic equivalence of different drug formulations ability issues that are of special importance to the drug regulatory authorities, and to industrial pharmacologists. Lately, in applied studies relating blood levels and EEG have applied pharmacokinetic principles to the EEG measures measures, and defined the halfuulife, peak effect and volume distribution of sub— stances as they afftct the brain ~— another important issue for regu» latory authorities and industry. we to other research principii of cannabis in naive and chronic cannabis users; the interaction of opiates and their antagonists; the study of alcohol antagonists; and to examine brain function in convulsive therapy and in psychiatric patients who have failed to respond to the expected treatment where EEG measures provide the basis to specify an alternate treatment. topics ~~ These methods have also been-applied study of the active Perhaps this issue is of more interest to your readers -— surely of greater personal interest to me. I would be pleased to meet to discuss either or both these ideas. Hopefully, the talents of the writers of Fhrtune could be put to a broader understanding of these scientific and socially relevant problems. it is My best to your family. Sincerely yours, Fink, M. D. Professor of Psychiatry Max MF:ed � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: McQuade, W. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-028-1-065 Date A point or period of time associated with an event in the lifecycle of the resource 1975 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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