http://exhibits.library.stonybrook.edu/mfp/files/original/dec4d2fc9f37ddede5a17df1654bf617.pdf b57d9e3d6e7bd4c53cb56c8f22883142 PDF Text Text W STATE UNIVERSITY OF NEW YORK AT STONY BROOK Health Sciences Center - School of Medicine Department of Psychiatry and Behavioral Science Psychopharmacology — EEG Stony Brook. N. Y. 11794 Phone: 516-444-2447 Laboratory April 2, P. H. Van Oot, 1975 M. D. University of British Columbia Department of Psychology 2075 Wesbrook Place The Vancouver, B.C. Canada, V6T 1W5 Dear Dr. Van OOt, still It is good to hear that seizures and seizure therapy are of research interest. Your finding of increased tonus in successive seizures is ‘consistent with the experience that repeated seizures are followed by a lowering of the seizure threshold. When current factors are held constant, successive seizures exhibit prolonged duration. Spinal fluid acetylcholine levels rise and the characteristics of the seizure change so that the post—seizure EEG shows longer and longer silent periods. The interseizure EEG becomes slower in frequency and higher in amplitude, and the duration of persistent slowing is directly related to number, frequency and intensity of seizures. Thus your observation is a facet of the oft—described neurophysiological consequences of repeated induced seizures. I trust that in your report, you present data for varying intensities of currents, and varying numbers of seizures. comment on the interaction of alcohol and note suggests the finding was a surprise. Surely, effects of seizures and of alcohol should make It is not possible to induced seizures. reference to the Your CNS synergism a possibility. Fortunately, such synergism (if indeed it exists) is not common in clinical practice. One would hope, should you pursue this line‘of inquiry, that quency of ECS; dose you would carefully specify number and of alcohol; and the time factors. fre— principal reason for answering is to comment on the tone of It is a potentially anthropomorphism in your letter. Rats are not unfortunate extrapolation to speak of "dangerou interaction" and to join ECT, alcohol addiction and dependence in as complex, unclear My sentence. HEM. �P.H. Van Oot, I M. D. April —2— O C- a 1975 recall citations relevant to the question of although there are anecdotal reports of ECT used successfully in opiate and alcohol addicts. I have not examined alcohol and cannot ECT, this combination directly. For references you may seek the studies of George Winokur in alcoholism and depression; and Ferris Pitts in ECT. I can recommend the volume, ”Psychobiology of Convulsive .Winston, Washington, 197M) and the January, 1972 ”Therapy", issue of Seminars in Psychiatry as sources of review of the neuroof ECT. fghysio ogy (V. , Sincerely yours, Fink, M. D. Professor of Psychiatry Ilax Merd � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Van Oot, P.H. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-028-1-042 Date A point or period of time associated with an event in the lifecycle of the resource 1975 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence