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                  <text>19 March 1974

Isaac Marks,

M.D.

Institute of Psychiotty
do Groupigoy Park
Dcnmork,ﬂill
London 8E5 8A3
EEGLARD

Door Dr. Marks:

First, lot no thank you for your participation in the APPA
settings. You: contribution was vary helpful, and I trout that

you cnjoyod tho ocooiana as ouch on

I did.

I havo rcod the proposed rosoaroh program untitled

youtio Studio: of Booiotant Noutoooo."

"Thora~

yroposcl is an ambitious one and should make significant
contributions to the trootmont of thooc complex problems. From
the point of vicw of poychoohormccology, I can one no inherent
rationale for tho study of clooiprooioo. From the evident: avail~
oblo to no, this is on octivo thymolcptio, prdbably indistinguishable
from imipranino. Tho study will doiino tho efficacy of this
compound and will soroly juotify the invoatuont.
The

the point of viow of nouroohyaioioay, I bcliovo that
in a much stronger position to dofioc tho rolo of
the pharmacologic ngoot in tho trootooot process if you could
specify that brain changooudid or did not occur, the dcgrco to
which tho changoo wore contained, and tho relation to tho troutuont couroo. A: I iodicatod in my lecture, I bcliovo that thorn
in a good tolationohip botwooo bohaviorol changos and nouro~
physiologic offooto in ECT, and with psychoactiVo drugo. Should
you be able to racetd EEG signals in a oyotoootic way, undo:
roooonobly woll—controllod conditions, your cloctrooocophologrophor could quantity tho EEG ohangoo and provide you with an
indopoodout nocouro of drug affect.
From

you would ha

-1-

�rm-

«-..-v

Ava“):

wwmrr

I. Markl‘

19 Match 1974

~2~

M.D.

Should you not have facilitias available at Denmark Hill,
wuuld be glad to coopnrata and provida you with quantifina~
tion of tapes; if these are «ollncaad in a ayatcnatic way. under
canditiana which permit us ca nuke tho measuranant. To c01ldborata with this laboratory would regatta thnt you havu a tape
system cangntible with aura, amplifinrs which era of ransonnbly
high.qua11ty, and a teghniciun who undnrutanda eh. presentation‘
of 339 data for quantitativu mcaaurcunnt. Thar: axe rwo technicians in tha Landon urea and, dhauld.you be intotcntad, I can
string: to: your technician to be superviaod by cithcr of those
um

units which

new

at: caapnratins with us.

During uh: pat: year, I have bacon: particularly interested
Eh.
in
psychoactiva.prapert1us of a tttraeyclic campaund. nianu
auxin (GB-94), praaucad by H. V. Orguuon in Holland.' We bilieva

that niunnariﬁ is

rapidly aetivn than anitriptyliue, with
fiﬂit scdntivu tad taxicholincrgic effects. Should you be intaraatod in alias this compound.rlthcr’thtn annthar in your emu
periunnt, I would be.gind»£o propose to the pharmneoloxistn at
mere

Orgauen that they canaider providing you with such equipnnnc as
gay bu unctul far a cbllabaraciaa.

I

hopu ynur weak;

.My

best rugsrds,

in Israel are fruitful.
,

Sincerely yours,
Max

rink,

M.D.

_

Ptofcsnnr of Psychiatry
Mr/cia
Baal.

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              <text>Correspondence to: Senay, Edward C.</text>
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              <text>1974 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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