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                  <text>March 28 , 1971;

Jonathan 0. Cole, M.D.
Boston State Hospital
Boston, Massachusetts
Dear Jon,

Enclosed are some of the forms that we are now using
to maintain alertness in our subjects and to assess changes in
behavior during our phasewI EEG classification trials. Our
principal method of assessing behavioral change is to ask the
subjects to open their eyes every h minute and 20 seconds (and‘
to keep eyes open for ho seconds), asking: "Do you feel any
change ?" Alternate inquiries add,
"On

a scale of

—6

to +6, would you rate any change in

your state of alertness (awareness)?" The subjects are told at
the onset of the experiment that their present state is to be
rated as '0’.

The symptom questionnaire is used befbre, at the mid~point
of the experiment, and after the experiment is over. Examiner asks
and notes responses.

a self rating completed by the subject before the
experiment, at the mid—point, and at the end. Rating is either by
hand or by computer program.
CMS:

Irwin inquiry: an open—ended sheet to maintain a running log
of the subject‘s behavior, answers to questions, movements, etc. In
the left columns, time is noted; 'as' is the alertness score given
by the subject;'bz' is the number of times a hand—held buzzer was
released during the previous time period; and '123’ reflects another
scoring estimate used by us in examining the effects of benzodiaz—
epines, and not relevant for your work. Page 2 of the inquiry is
completed at the end of the experiment.
From

this range of behavioral inquiries,

we

believe

we

have teased out some aspects of the subtle behavioral changes in
our subjects when we have used threshold doses of novel and established
compounds.

I

trust these

comments

are helpftl.

Good

luck

!

Sincerely yours,
Max

Fink, Mb.

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              <text>Correspondence to: Bobon, D.P.</text>
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              <text>1974 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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