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                  <text>12

April

197%

ARIK BRISSEHDEN, M. D.

V. A.

MAX

Hospital

'

PINK, M. D.

Treatment of Chronic Schizophrenia with Oral Hypoglycemic Agents

his

I have read the protocol submitted by

co—workers, and would approve the mission.

Dr. Messinger and

There

is a theo«

reticel objection to this study, since ineulin come therapy has
been found to be thoroughly ineffective in the treatment of
schizophrenia. Hypoglycemia may not alter cerebral activity until
levels lower than

achieved fOr extended periods.
For both these reasons, I would assume that the treatment yroposed
is essentially a placebo thereepy with smell additional risk.
30 mg% have been

However, the risks are small, even acknowledging the
caraiovasculer risk assessed by Dr. Fritts. If we acknowledge
that the therapeutic effect of enthusiasm of the observer and
systematic observations may be mobilized for the treatment of some
patients; I do recommend approval of this project because I believe that Dr. Messinger will be stimulated by his enthusiasm and
we can anticipate some discharges from the hoepitel using this
regimen. I would be less sanguine about their finding meaningful

scientific data.

MF:ed

-

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              <text>Correspondence to: Kletzkin, Milton</text>
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              <text>1974 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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