http://exhibits.library.stonybrook.edu/mfp/files/original/d0c376d4f2aa112ff1d3cdd553203855.pdf 0e4995bf528f9b6824dd02e420b5fa81 PDF Text Text May Riezen, Honk van Scientific 30, lQTh D. M. Development Group H.V Organon Oso , Holland Dear Bank: First, let me apologize for not having reported earlier; two weeka ago, I was concerned that my impressions may have been in error, and knowing that she would be but, after visiting Joyce at the her. meetings. I waited to confirm.my observations with Following are some notes concerning our projects. ECDEU chewed me is directly involved with these studies.‘ Their optia in studies of OI~63 was in marked contrast to their pessimism Milstein mism with 1. Jozpe Small. I visited Indianapolis on may 7. Joyce through the laboratories and we were accompanied by Victor who GB~9h. They have completed nine subjects in the series, and in no instance have they been able to avoid ECT. While none of the patients exhibited a clinical.woraening, none im» proved sufficiently to provide any feeling of optimism. When I enquired about side effects, she called her nurse—monitor who seemed comforteble with the drug and unable to identify symptoms that were problems to the patients. There were no "anticholincrgie" symptoms. But Joyce's questions were sharp and her statements stronger than the date seemed to warrant. I become concerned that we may be seeing the development of e halo effect, i.e., the failure of the first few patienta to improve markedly has set the etege for a negative evaluation. She asked me whether she could discontinue the study after ten subjects without 'breaking her worn’ to you. (In discuseing this in Florida, she was more negative than the date considering the very severe test to'which the drug was warranted, put . a. ‘- I' wwwmm.w«nnnz 'v’. s ‘2. m rang: I] r 03— h: �Hank van Riezen May —2— 30, 197h I suggested she complete ten subjects, summarize her observations, send the reports to you (me), and not induct any new patients into this study until these data have been digested. b. OI~6§: This study is progressing well. Enclosed sheet data summarizing her observations in nine subjects to the is a end of April. She finds 01-63 to have little effect in the immediate post-seizure recall period, but may improve recall at twenty— four hours. She is anxious to go to the next groupof subjects, in the same design, but at the higher dosage of 30 mg. I found this suggestion reasonable, and encouraged her to proceed. She and Dr. Milstein indicated that they were also re-assessing the memory tests and they seemed pleased that some of the methods they have developed had shown differences in OI~63 effects. Some additional tasks are being tested at the same time as these studies are in progress. Both she and Dr. Milstein were somewhat depressed, however, about their local funding and space problems, reporting that some of their grantgs had not been approved, and that she was anxious to-obtain additional industry support for studies. Joyce has collected tapes of EEG data with 01-63 and is a unique 8—channel, l/h inch, General Precision instrument which is no longer made. _Failing to find one in New York, I decided to send a member of my staff (Peter Irwin) GB-Qh. Her tape recorder with one of my h—channel recorders to Indianapolis to transcribe the data from her tapes to mine; and we will then analyse the data here (unless you prefer to use these tapes to test your system in 035?). ;I have set a date for June lB-lh for the transcription. ,, w. .. 1-,_.-., am .v:. “View”: ‘qzvrr-rzn ) -—-: rm-zwsafir'nn Lyman-or .1 14"‘A—W1n-mvimnjwy‘” I have had (Joyce gave a little visitor's and send them to packet of her programs; for your.information.) you the presenwell received. '(Please edit it of the report is and I would be grateful for any corrections of fact or-nuance that you may suggest.) The diacussion was started by Joyce, who reported that she completed nine subjects in the ECT paradigm; that there was improved recall of learned material twentybfour hours 2. ECDEU: The meeting was well attended, ACTH Peptides on Memory and Brain A copy enclosed. l,tation "Effects of 5 me these copied and Function" was �Hank van Riezen «3~ May 30, l97h after the seizure; and that the effects were not evident in the immediate post—seizure recall. She was encouraged by the find~ ings, and said she was extending the sample at a higher dose of 30 mg. Others enquired about the similarity of 01—63 to UCB (prracetam) and to Unger's compound availability of the materials. (scotophobin), and to the timely because the next afternoon was in depression and schizophrenia. The N data was sparse, with the usual of four to ten in each study. Hoeehst was well represented (six visitors) and Dr. Alan Gordon summarized the findings of European studies as equivocal or nega— tive in depression. He reported sleep EEG studies, which failed to show an effect of TRF. Drs. Prange, Lipton, Hollister and Huey individually reported small studies without consistent findings in depressed and schizophrenic patients. Yet, each reporter apologized for the paucity of the results; described some anecdotal, single cases that were remarkable; and suggested that some findings were there, although they did not know how to extract them. Itil presented EEG and the clinical data from Turkey, and his report was optimistic and constructive. He reported well defined EEG changes, similar to dextroamphetamine, with clinical effects in depressed patients of short duration, with self reports more positive than observer ratings. There was some criticism of his report, notably the question by Gordon that since he could not find EEG effects of TRF in the sleep record, how did Itil explain his findings in the alert subject. This gave Itil an opportunity to describe the differences in methodology, the problems with sleep assays, and the necessity for quantitative methods. The presentation devoted to reports of was TRF (TRH) I was left with the impression, both by the interest of the reporters and the audience, that the peptides were now among us, and that much study will have to be done in the next few years defining their activity and developing new methods of analysis. A few investigators (N. Kline. D.F. Klein, J. Simeon, L. Hollister, R. Shader) asked about the report and 01—63, and I will send copies of the report to them, hoping that their interest has been aroused. I am sending a copy of the report to the editor of Psychopharmacology Bulletin for her consideration for inclusion in a ferthcoming issue. �~h—~ Henk van Riesen May 30. 197k 3. FDA Report and Dr. Ksstin: I have decided to send the report I have given to the ECDEU, as well as a covering letter describing the date of the Miller and the Fink studies. I will omit reference to the recent Kastin end Sandman reports. Abba sent me the latest report with a covering letter that seemed unnecessarily harsh. However, I am willing to serve in the re— lationship with him being acutely aware of his idiosyncratic and irritating behavior, but accepting these as necessary accompani— ments of the program. the FDA In reading Ksstin's letter to you of April 29, I found references to a study of ? OI—63 in schizophrenic patients. I have not heard from Kastin regarding this study. Should he wish to file an amendment again, and to avoid the criticism that we ‘are holding him up, I am writing to him directly (enclosed). I Because h. Essman: I read the Essman letter and the two scales. these confusing, I called hhn,snd he explained found He derived from some studies by that the tasks were Squire. 'esserted that the tests have had some reliability testing (two forms) and at least two applications. It should be interesting and if they are sensitive to memory loss (recent and remote), then thetpplication of the tests may be to read these reports useful in the 5. Klein2 D. F.: we met in Florida (although we live some community, I tend to see him in fer-away places) and He wished to read the reports which basis of my peptide summary, and I gave him a duplicate set that I had with me. I shall send him a copy of the ECDEU report and try to meet with him in Great Neck in the next two began a discussion of OI~63. were the weeks. I have received a letter from Jack regarding the visit U. S. for a review of the date analyses of GB~9h, and I have made arrangements for Drs. Boneto and Guy of the Biometric to the Laboratory in Washington to assist us. I have become even more interested in the peptides since the summary, and I look forward to listening at Utrecht in writing my best regards. Sincerely yours, Man MF:ed 'Enclosures Fink,_M. D. Professor of Psychiatry , � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Barclay, Gordon Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-027-6-443 Date A point or period of time associated with an event in the lifecycle of the resource 1974 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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