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                  <text>v..w“"‘

VIV'Wn-u-vwwm

May

Lyle Miller,

M.

Yximmiwumﬂwntmvﬁ‘w"all-'wv

:W

mm:

"'mw

D.

Eastern Pennsylvania Psychiatric Institute
Henry Avenue and Abbotteford Road
Philadelphia, Pennsylvania
Deer Lyle:

I put your letter of April 18 aside as I was trying
summarize the peptide literature for a meeting of the ECDEU.
am Inllosing a copy of that summary for your information.

up,

wﬁuﬂ?'—"‘

30, 197k

to
I

outline of a study of 'ACTH h~10 and Attention'
and as soon as you have the protocol in better shape,

The proposed

is interesting

I would have little difficulty in processing it.
to the dosage. Is not 10 mg low? Why not 30 mg?

One

question is

Regarding your comment on our 01—63 date, we have
studied the changes in alertness with placebo in our subjects,
and do find that it decreases in time. For some substances,
alertness is maintained, and this is defined as a drug effect.
In the 01-63 study, we did note the change in alertness, but were
not sure that the change was sufficient to be a drug effect. We
attempted to re~exemine at higher doses, and may have ignored a
finding. since a re~examinstion shows the same changes at higher
-doses. Thanks.

I look forward to reading the protocol of the suggested
Estudy, particularly the selection of the OPT task.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

Encl.

'

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              <text>Correspondence to: van Riezen, Henk</text>
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