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                  <text>7453-07283
12

rahruary 197k

M E HVO R

A.N

To:

Wilton w.-Shroava, M.D., Ph.D.
Acting Associate Chief of Staff for Raunarah

D U H

VAR-Hoxthpor:

Fink. M;D.
Protaaaor of Psychiatry

From:

Max

subjact: Propoual of Dru.

Sn and Boson, "Molecular Modal

of Morphina Dopandanca"

Ra:

632/151. 2/1/74

is a basic acianaa investigation of hypotheses
of abronic opiate use.
tho
pathophyaiolosy
eonaarning
The study

Dru. Sn and Boson propoaa to no: tho oholinargie aspacta
of the nouronnscular junction of rat diaphragm to stamina the
oignifiaanca of acatylcholinc inoraaaa in dependence and ab~
atinanaa. The study in wall daaignad. tho nathoda are faaaihla,
and tho authors hart axparicnca in using these nathods.

prison: version of the yroyoaal is very much improved,
with an axonllont rationale and a more detailod praaontation
The

of methods.

Tho study does not involve human

subjects.

The authors toquaat tho VA to outablish the laboratory and
request no funds for pataonanl and only limited ouﬁpiina during*
aha firat your. Thu oaoond~yaat augment in modaat, consisting
half in aquipuont and half in taohniaian support and supplies.

Racoamaggation:

If ch.

VA

in ahla to provida basic science

laboratory aquipnant for a nonrpatianc~oara effort through itsand
establiohad grant machaniama, than tho hodgat is appropriate

relevant. avan mode-t.
Approval
MF/cia

is

reconnaodad in the amounts raquaatad.

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