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                  <text>_H.

A.

,

.VVWTWN...

.A.

..
A

.viv'rr-Mn—Av

-.

.

.wwmqup—gyw-xww

-»-

7383-79483
28 Novembor 1973

Robert 3. Robinson. M.D.

Houropharmaoology Suction
A. 1!. Robin: Company

1407-Cumoinsn Drive
Richmond, Virginia 23220
Dear Dr. Robinson:

I havo just rotnrnod from a trip to Europe and boon tovieuod your lotto: regarding tho EKG chanson associatod with
lonporono (Aan2277). I do not know how to interprot the
data prooontod banana. we have bocono ocouotonnd to finding
ouch EKG changes with many of tho anti-psychotic compounds.

your: ago Dr. Itil and I become oonoernod with this quoo~
tion and in a oyotonotic study o‘ thioridnsinn and chlordinso—
potion oolloctod the out. carefully and had then ovaluntod by
two interniuto. Wu worn inpronand that the EEG ohongos induced
by thioridanino wore significantly groator than those induced
by chlozdiaxopoxido. In a oooond study. patients receiving
fluphonozino. thiothixono. and haloporidol wore examined for
EKG offoots.
In this study. the group of patients had favor
EKG changes than the patients who had rocoivod thioridnxino.
Sinco than I have followod the literature carofnlly and note
tho studios of Ban and Lebanon, Gallant. and Simpson. Each
of that: author: has indiontod that tho EKG changoo following
thioridnnino worn much groatot than othor anti-psychotic dross.
Bonn

it

When looperono cons: to Phase III touting,
tight be
odvioablo for you to connider a direct comparison of its cardio»

vascular affects with tbioridasino and one other anti~poyohotio
compound.

with razord to out own work. our doses are much smaller

and we

anticipate

no

direct outdio-vooculnr difficulty. I
this to my attention.

thank you, however, for bringing

-1-

�,WW-‘Yq‘
'7

..

‘

E. E. Robinson. K.D.

28 Havanbnt 1973

*Zw

Rt have continnad our doaa~£1nd1ns studio: and
now
looking with stutter detail at ch. EEG tad behavioralarteffects
of 3 and 6 as domes.
My

bust regards.
Sinaotcly yours,
Max

rink,

H.D.

Professor of rlychiutry

MF/cts

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              <text>Correspondence to: Klett, James</text>
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              <text>1973 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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