http://exhibits.library.stonybrook.edu/mfp/files/original/23127ea249bf7cacd93a9754919e2b63.pdf 3d5c587903381456d3e0fe430d351cd3 PDF Text Text .. «r J».,,_,‘__..,..V.... ' 73SB~81883 m‘mwwmnavu-WF' 19 December 1973 ‘3 ‘ — 11mm 1.7mm ~v-v«'-vo~"!01"rr .W'Vinrvu-grm—«w. Julian J. Leaky, Ph.D. Executive Secretary Clinical Projects Research Review Committee Division of Extramural Research Programs National Institute of Mental Health lOCZS--Parklewn Building 5600 Fishers Lane Rockville, Maryland 20852 Room Re: '5'" MB 25608-01 A .«— »- 7" gq. w, Dear Jack: I have read the proposal, "EEG and Changes during PsyDr. Reilly proposes VER Reilly. psychiatric patients (N - 24). In addition to a psychiatric evaluation using rating scales for mental status, he proposes a systematic EEG recording for back— ground EEG by visual interpretation, and for the visual evoked response. Recordings will be done prior to drug treatment and at weekly intervals for the duration of hospitalization, for at least six weeks. He also proposes monthly recordings thereafter between the second and sixth months. The date are to be snalysed by complex statistical procedures of a multivariate type by consultants who are experienced in statistical analyses but chiatric Treatment" by Dr. E. L. to examine a small population of not EEG. The mission set by Dr. Reilly is a most commendable one. the problem and My comments can be divided into four sections: and conclusions. methods, facilities, significance, 1. Problem and Methods The problem selected by Dr. Reilly is a significant one. In the description of the EEG recording and visual analyses, he describes acceptable methods reflecting his experience as an electroencephalographer. However, to describe a project in 1973 using visual description methods of a decade earlier may reflect a lack of experience with newer methods of EEG quan— tification. If the choice is based on data, then he should ~'»£Jfl'M"w":/“I -1- �.- .....A. J. J. Leaky, explain problem. I -2- Ph.D. why he uses 19 December 1973 non-quantitative methods for a quantitative concerned with the diagnostic criteria for psychiatric It is unclear whether Dr. Reilly has the experience to select patients carefully, as the problem requires. (This question should be answered in a site visit.) am evaluation. I am also concerned with the one-to-two-day drug-free period prior to the initial EEG. Considering the wide use of drugs, varied dosages, etc.. this is inadequate. I do not have a good solution, but I would recommend placing all patients in a defined group on the same medication for a specific period of time before the EEG. issue of diagnosis—related EEG measreported that the die differences were a more parsiménious explanation of the differences found between schizophrenics and depressives. Dr. Reilly does not indicate an awareness of this major pitfall in such research. ures When we some examined the years ago, we Thus the issue of quantification, psychiatric diagnosis,‘ medication and age controls, in addition th the small sample, make me question the likelihood that the goal will be reached. The application is also unclear as to whether VER, or resting are the foci of the study. The application lacks a specific hypothesis reflecting potential effects in either measure. EEG, 2. 'Facilities The physical facilities seem adequate to the task, although I anticipate that Dr. Reilly will find that recordings made on a Becknsn recorder will not be satisfactory for computer pro, ceasing. ”n“...- .r, :y-rvlcn—‘vr «mnp- .r. ”,1 ”WW, wwwme 1“,. rm— Dr. Reilly's training seems adequate for EEG and his coworkers are physiologists and statisticians. The participation of a psychiatrist (a behavioral typologist) seems lacking in the study. ' The funds requested seem unusually modest. Considering the talents ascribed to the consultants, the sun requested ($3,000) and the computer tine ($600) are inadequate for the analyses described in the text. While modesty may be a factor, I believe lack of experience is a better explanation. �J. J. Leaky. Ph.D. 3. 19 December 1973 ~3~ - Significance of physiological indices for the classification of the mentally ill and for the description of changes in psychiatric treatment are very important issues. The problem has The problem been approached by many investigators. The literature survey presented by Dr. Reilly is adequate, although there are significant omissions, particularly the studies of Shagass, Callaway, and Monroe. Again, the references to clinical electroancephalographers, especially those associated with Knott, Wilson, and Doty, are well reported, but the contributions to this problem by psychopathologists are lacking. 4. Conclusions cannot help feeling that Dr. Reilly is an enthusiastic in climbing a small hill in the lower Appalachian Mountains, who became excited with the possibility of scaling Annapurna. The goal is commendable, but he seems to have learned only the rudiments necessary for this task, and 1 young man, experienced I do not believe that the prognosis for success is favorable. But how can one encourage such an sible to recommend that he spend it poswith Callaway, interest? Is some time Shagese, J. Small or Itil to obtain additional psychiatric experience relevant to the problem which interests him? I would also suggest, if one can, that he become acquainted with Neil Burch and Peter Kellaway, both in Houston. These men understand EEG measurement and can probably contribute to his data processing. He should become acquainted with either Bernard Salteberg of Tulane or Stanley Feldstein of the University of Maryland. Both of these men have devoted many years' effort to the statistical analysis of complex EEG data, Seltrberg with Burch and Feldstein with me. (I would ask that he be advised of the work of Dr. Burdh, for on Page 21 he says, "There is no other source of the programs in running form available in Houston." It is my understanding that Dr. Burch has had quantitative EEG programs for background 339 and probably AER in running form since 1966.) ' I trust these comments are helpful. I believe a be encouraged to climb mountains when he has had man should sufficient ex— perience to handle these problems-~for climbing the mountain that he has targetted is a worthwhile experience. �“0 “a, -m. w- ‘ ._.v,,.‘ A ,. < . V. J. J. Lalky, Hub. -4- 19 Dgcambat 1973 u,v .. . Thank you Sinceruly, .v-:rw.<wmn—vu_.-—.A..Y.... Fink, MOD. Prafansor of Psychiatry M‘x -.wr7l=r a,” H for the opportunity to rcviaw this application. Hrfcis M � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. 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