http://exhibits.library.stonybrook.edu/mfp/files/original/65cf9ce0881bdb1342f68680236db04d.pdf 97d7643af9c51a7f4a8aae11a9b9af3f PDF Text Text «r. Wrr‘wi’I—v' 7333—723 June 213t. 1973 George Gerdos. R.D.. Boston State Hospital, Boston, Mesa. 0212h. Dear George; I have read your paper "Low Dose Thiothixens in Chronic Bohisophrenia" with much interest, and have a few comments shout the issues that meet interest as. The references to the effects appear to he incomplete. olerify whet the study record shows that the heheviorel changes EEG and are put in a context ihieh does not eon-unicetee to me. The that the dropout rate was high. There were few differences in clinical effects betveen the low and high dose thiothixsne groups. In yartieularl this reflects a very'high dropout rate. The significant changes vere a reduction in were small and aneooperstivenoss with high dose, and a decrease in depression with low dose. It is imwortant to note that concurrent with these linited differences in behavior, there were smell but defined difference: in BIG. Kore, too, the level of significance was low. largely because of the e-all sample. But you could safely report that high dose thiothixene elicited a lower average frequency. reflecting an increase in theta and alpha activity, and a decrease in beta activity (Table 8. 888 report revised 2/12/73). Should you.ooneider the behavioral data of significance. I believe you ought to report the EEG data of equal significance. for the high doses did elicit KEG Ghansss of the anti hotie class. according to my classification (and that or Itil . Low doses did not prodnds say evidence of stimulation (defined as increased bets. increased variability and decreased ssplituds), lo the extent that you wish to use these observations. I would conclude that the hypothesis that low doses yrodues stimulation is not supported. than �George Gerdoe, M.D. 1913 psychoactive drugs. Theee observatione with high dose showing smell ehengee - inereeeee in that: end elphe eetivity. which eeeonmenied.behewiore1 improvement in some yetiente end e reduction in nneooperetiveneee — 1e eoneietent with our general hypothesis of the eeeooietion of 236 end behavior in nan. \ the questions that we tried to enewer wee whither differed in their initial BEE eherenterietiee. When we eeeeeeed the EEG eherenterietiee or the eubjeete et the end or placebo with those et the end of low done. we found no eignirioent differences, which led ue to conclude that the eleplee were honogeneoue at the outeet. In your analysis or the hehewiorel date. I mien this ennlywie, It is not clear whether covariance wee e technique epplied to your ante. which would enlwer my question; or whether none other teete for homogeneity prior to treetnent were introduced. I mention this because yen'preeent the beheviorel ante (your Table 2) in terms of poet eooree only, and I believe the reader is entitled to know whether these differences are releted to initial poeition. the Amont two groan: it Since you eent me the original. I en.returning to an interesting retort end with the enell enendnente which I suggeet, I would encourege its publication‘ you. It ie we've-e regards. Sincerely yours. we: Pink, M.D. Profeeeor or Peyohietry ,nu i Zlet. thiothixene w-«ww: ”wan- June It: neny year: I have been eeeking to nnderetnnd the relationship between EEG ehencee end behavioral ehenaee with nu. w-nwr—m '-2— Illid nee. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. 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Title A name given to the resource Correspondence to: Duffy, Richard Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-027-2-151 Date A point or period of time associated with an event in the lifecycle of the resource 1973 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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