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                  <text>7333603~

April 2nd, 1973

Professor: E. Eﬁnkel

and 0. Doloe,
Medisinieohe Hoohsehnle Hennover.
Abteiluns {ﬁr Elia, Neurophysiologie and Exp. Heurologie.
3000 Hennover~xleete1d,
Khrldwiechert~A11ee 9,
Gerunny.

Door Profeeaore Kﬁnkel and Doloe,

I receivod your kind invitation to participate in the
in 197%. The ides 1e tiaoly end I look forward to
perticiyeting.
The outline augment: that near intereete V111 be diseuneedz
the technical problems of date acquisition, reduotion of EEG
and etetietloel pwooeeeing, equiouent (particularly oomgutere).
GEAR

end «polioetions. Bone tonnes. soon :3 eoqnieition, date radiation
and elolyuie. are similar for all projecte. But the epolioetion
or these nethodn differ widely, whether the subjects are men or
eniuele. Shoold the eonferenoe focus on issues both in men and
in animals. I fear that your wish for a “smell" conference vill
be unfulfilled. I autumn that your primary interest is in the

application of these

methods

to studios in

men.

As you know, my eseooietes not I established a ldboretory
for oomguter ennlylit of EEG in St. Louis in 1963, and a second
one in New York in 1967. We next been interested for these men:
your: in upgaying the methods of oooputer ennlynie to different
problem: in peyohophernnoolosy. at now use our methods to
obtain the neuron uiologie grortle of new oompounde (phase I
peyohopharneoology ; and to moeeure the bioevnildbility (neuro~
physiolosio equivalence) of different formulations of payohotropio
drugs. By these methods we hero studied clinically accepted
compounds. preeuned compounds. and such eeoterio topics on
eenndbie, opiates and their antagonists, and induced ueieuree (BOT).
we but. devotea much tine to many technical issues. as the
different analytio yoogrene (power spectre, period eaelyeie.
maplitude integration, vuridbility meeluree), the problems of
the tangle 01:0. etetiatioe (univnriete versus multivariate,
regression vorlun dinerininete function) eta.

�Profs.

H. Kinkel and G. Dulce

~2~

April 2nd. 1973

the provisional aniline. I an pleasad to recommend a
at pines: whare we might honiribute to the grogrnml

From

anubnr

2.1 Camparixon or power spectral dcnuitz, /!‘riod
analysihlund amplitude analyait.
3:2 Proeaaaing EEG data ” statistical applicutions.
’

3.1 (3.5)
‘3.6

EKG

EEG

clansifioaiion or psyehhnetive drugs.

analysia.

h.3 and k.h The

ta

\\

DEC

-

IBM

1800

statistical

PD? 12 (and PD?

15).

package; aonvornion

come at thhne technical subjeats
presented, I would recaanand that you invite my coworhar of many
years. Bunmld M. shapiro,rD.B¢., fur his knowledge of camputer
method: as applied to EEG. (Ha has programmed the IBM 1710,
1800, and 360/ho; also DECi'PDP 12 and 15).

should run wish to have

Alaq’Dr. Shapiro and I havn been instrumantal in estdhlishing
a laborahary for EEG analysis at N. V. Orgauon in 03s. Bollnnd.
Their oomgutor director, James Porsak, had programmnd an IBM
system in Detroit, and is reiponaihle far programming the PD? 15
in 033. He is very knawiodsahla dbcut lacuna in Sectiaha 1, 2
and h at your outline, and I caauend him highly.

I am taking the liberty of onelosing a few raprinxa from
this laboratory which mny‘be rclevant ta your pragrsm. As you
will find, the bolt is that which is at yet unpublished. and I
ma dhle only to send you yrcprints.

I command yen for undertaking such tn arganiaationalgthsk,
I look forward to tho CEAN acutingn with great anticipation.
I thank yau for yhur invitation and trust that I will hnvc an
apportunity to diseual this with you on can or my trips to Europe
and

in tha farthhcning months.
my

best regards.
Sincerely'ynnrn,

Fink, Md).
Professor of Paynhiatry
Max

MF/iJ

Each.

/

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