http://exhibits.library.stonybrook.edu/mfp/files/original/e7901b1fa6b412b5e6c64d5e16217138.pdf a1762c0563c354f5f5ea62e8ccbdfc8c PDF Text Text TSBBnSRl April 13th, 1973 Mr. John R. Coastline. Karootie Investigator, Suffolk County Health Dept., Hospital Affairs Division. Route #113. Riverlsigh Awa.. Riverhead, N.Y. Dear Mr. Cossolino. I am pleased to give you tho following summary of our use of Schedule I drugs at the Health Sciences Cantor. «pr-1 my”- -‘—va. rpm-rye: F’s'" m war. . l. The principal study program is an evaluation of narcotic antagonists and narcotic substitutes in the treatment of opiate dependence. This study is in two parts an experinentsl part at the university and a clinical part at the Veterans Aflministration Ebspital in Horthport. This study program is supported by a contract from the National Institute of mental Health, HEM h2—72—llS (Antagonists to — Opiates). In the olinicsl program at the V.A. Hospital in Horthyort, we are treating veterans she have been using opiates for two years or longer with oyolssooins. methadone, lavomethadyl (l~alphs—acetylmsthsdol) and naltrexone. As part of this program we also use heroin ehallenges. During the next svo years we anticipate expanding the substances to be tested to include diprenorphine of range and 302605, as narcotio antagonists, and such other opiates as may be of interest in order to define their duration of action. 1n- 5W “cw“mvm arm“ V Specifically, patients vith a two year history of opiate use are examined and based on their psychological eharaoteristios. recommended for maintenance or dooonditionins therayw. It maintenance therapy. we follow the FDA guidelines for the treatment with methadone. Approximately one half of the subjects are maintained on lav dose methadone (upgrox. SO as) �Mr. John R. 001501130 ~2~ Agril 13th, 1973 and half an high dose (approx. 100 mg). During the ncxt month a portion of tho patients who have been on methadone ten months or longer will b: trtnsferrad to lawnmothndyl at 80 mg thren tinns a week. This, too. will fallow FDA rusulationa. Sam. patients are inducted into deaonditioning thnrayy in which they reeeive cynlnaoeine up to h mg a day (or beginning July, naltruxona to 100 mg a day). At these blockade is donagaa measured by challenges with heroin or morphing. usually 25 mg of auch. In the experimnntal program ut thg university, um are attampting to find the EEG and other phytiologie effects of vurioun substances. unler this contract 9! are assessing the EEG effects of naitroxona, morphing, diacetylnorphina. etorphina, and extruetl o! cannabis. A yortion of this work is supported hy MK 2&020 "EEG in fliman Psychopharmacology",' a grant from the HIMH. — In this program suitable voluntecru are given participating experiment: in the EEG labdratory and for patina: of up to six hours have phyniolagieal recording after adndnistration of one of the scheduled sfibstances. substannos are dalivared, they are usually sent office (at Stony Brook). Such supplies as may be naceassry at the Vbterans Administrutian Hbspital are trannshippea to the V.A. and maintainod in a safe similar to that which we have at the university. (Pbr methadonn and other aubstanaea usually available to thn V.A., we obtain our supyliaa tram the yharmney which maintains the basic anywlics and rcoorda,and delivers to us, in individual bottlas, drugs for individual patient: fur specitiad days). to Khan my 2. Fur a number or years at have been studying tbs smoking cannabis, hanhinh. ind various derivatives. such as TEC~delta~9, Tflc~deltn~8. cunnubiéiol and canndbinol on physiological maasures such an EEG, heart rata, respiratory rate, pupil 3130, ate. This wart was done in New York under RIMS grants, &na a eontract HEM h2—70~98. This contract included a study of chronic hashish usara in Greece. where um have 1159 examined the fikysiological attceta of that: antitancen in tents inhalation experiments. This part of thn wart in Grace: is continuing and.v¢ have reqnnstod funds to cantinue tho v.3. portion at tha Uhiveraity. effects of �‘Mr. John R. Ccaaclino April 13th, 1973 ~3~ In the laboratory vcrk, cuitcblc volunteer: inhale these substances in thc KEG laboratory and remain under supcrvinicn far periods up to eight hcurn. Physiological rnccrdingc are than analysed. 3. Am the present tins cm are negotiating a contract with thc V.A. for the ccmpcriacn of lunlphc~ccetylmcthadol and high and low dose methadonc in the maintenance of patients. This atuay, if it is fundcd, will he dcnc at the V.A. in ficrthport with cutpctiant units at still to be dcsignated‘tizci‘in thc County, one or which will he at thc \Hcalth Scicncea Center. are not limited in our studies ,6 Schedule I substances. but also access substances in Schedules II, III, IV, and v. Fbr all these atudies, for such substances as heroin, marihunna, THC, ccc.. supplies are obtained tram the NINE. we have in the past, and plan in the future, to obtain supplies of cannabis tram this source and transahip We these to the university of Athens under our contract Bhiymcnt is to Professor Costa: Stcfanin. at tbs University of Athens (Th, Vasilliasis Sophia: Ave., H83 h2—70a98. Athens. Greece). Occusianally we deal with substances which are sent to us by laboratories in Europe or the U.S. In the past, this has been true for hachish, etcrphine. and diprencrphine. As our studies continue, we anticipate immorting such othcr substances as may be necessary fcr our studies, and which may be similar to the one: already atudicd. 5.7- -(n' a»: a"... This stctcmcnt is submitted in support of our application for a licence to engage in research with controlled substances. I trust this infbrmation is useful. Thank ycu fbr your acsistance. Sincerely yours, max rink. M.D. Professor of Psychiatry MF/ij «1—sz . ’ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Robinson, Robert Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-027-1-101 Date A point or period of time associated with an event in the lifecycle of the resource 1973 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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