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                  <text>.,, ...v

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A.

73SB:09lSc

April 1h, 1973
Mr. Herman Heisman

Sr. Clinical Associate

Hoffmenn~Ls Roche, Inc.

Nutley,

ﬂew

Jersey

Dear Bank.

Following our discussions, I have revised the protocol
the ongoing study or the EEG profile of bromszepem (9 mg),
diszepem (10 mg) and placebo, with blood samples drawn for
fOr

assay of these substances and metabolites befbre and 30, 60
and 120 minutes after drug ingestion. A copy is enclosed for your
review and

files.

-

study began on Thursdny. In three sessions that we
encountered no difficulties beyond the discomfort of the
ran,
subjects at experiencing four withdrawals of blood. Should this
become a problem, we may have to increase the 'bonus' paid at
the end of each study.
The

we

my

best regards.
Sincerely yours,

Mex

Fink,

M.D.

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              <text>Correspondence to: Cozzolino, John R.</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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