http://exhibits.library.stonybrook.edu/mfp/files/original/a83a2a05e209e7c21e90f1c9112504fe.pdf df3f1896a573e9d6c6f21ed0022c65e7 PDF Text Text 731~631 April 19. 1973 Beynour Kety, M;D., Professor of Psychiatry. Ehrverd Mhdieal fichool, hissechnsetts General Hosyitel, Fruit Street. Boston, Ma”. 02121:. 5 Since reading the summary of the ECT conference. I have had time to reflect on the eenelusions. I as writing to reise some questions. not about the summery presentation. but the tonelusion of the role of cholinergic mechanisms. As I understand the relevant paragraphs (page: 5a6), the date for the role fbr seetyloholine ere unimgressive. and do not meet the ariterie fer relevance, set teeth in your earlier peregrephs. The persgrsph focuses on the report by Karcxsnr. years ago I reviewed the data relevant for a (1) I fbund the ehenges in cholinergie measures ta have s time tour-e similar to the heheviorel (end electrogrsphie) effects. (2) Specificity was herd to demonstrate, but eerehrel trenme and neurological illnesses did not exhibit the seas eholinergie effeets of seizures. (3) Using sntilhelinergie drugs, I was dble to reverse the electrogrsphia and behavioral effects of EflT. The date are not avervhehsing. but teken as a whole, the ante impressed me that eholinergie mechanisms were relevant to the ECT process. Some ahelinergie hypothesis. objection to the hypothesis is thst entheholinergic drugs. like Ditrqn, have elinieal entidepreesant activity; end the suggestion I msde in 1958 that iuiprnnine has entieholinergic activity also refleets on e eholinergic hypothesis. An In your summary in Doredo Beech. you viewed scetylcholine ss relevent to the seizure threshold and as reflecting the widespread activation of neurGBS“, without specificity. I thought then that your argument use cogent. Particularly, that seetyleholins. es en ubiquitous trunsmitter, may reflect the inpeet of the massive discharges oceseioned by the eeixure~ inducing agent. But this hytotheeis. of nonuepecifieity, is �Seymour Katy, on no more ~2- April 19, 1973 substantial footing than the suggestions of epeoiticity. Indeed, the more prudent course may be not to enticipete which neurohnaor is the more important, but to reflect on all. for the role of biogenie amines who evidence changes in protein synthenie in part, this may and is well documented. In reflect the availnbility of adequate and BOT toehnioelly simple methods of nnnlysie. In ooneidering the ohelinergio hypothesis, vn are faced by the technical problems and ineoouracy or hionsaay methods. Such difficulty must have contributed to the peueity or studies in ECT. I knoV'thnt this technical difficulty has deverely impeded my studies, for when we did biouetdye for AOh, we found them too unrelidble. But. from this vantage point, descriptions of improved methods for assaying acetylcholine (gas chromatography - mesa spectrometry en deeoribed by Jenden at the ACE? in 1972. is an exonple) encourage me that more adequate tests of oholinorgie hypotheses in ECT are feasible. will be read and en your opinion is highly valued. your conclusions may influence further studies of ECT. Alex did not present the oholinergio date well; and I Your summary cannot do better. Presuming on our companionship, I am enclosing a copy 1966 summary. The data are meager, but may be nutricient to quicken your interest in presenting the cholinergio date with slightly more optimism. Should you wish to do so, fine; thould you‘wish to ignore this point, I will not be offended. or my : "T 5-12-17va 3.9. you The volume in almost complete, and once again I thank and encouragement. for your advice my ":7'1(‘l ':3 best regards, Sincerely yours, nmwv-w— “If -r=: Mex 12m MF/id Ene. Fink, M.D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: McGaugh, James Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-027-1-090 Date A point or period of time associated with an event in the lifecycle of the resource 1973 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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