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                  <text>m‘rarw-~»~wwwr-u -&gt;W“'m’rr-w

«W‘~«.

v-Iwmt -,

me...

».n;, n

w

-

1-...

7313:09601'

April
Alin Giles,

2%

. 1973

M.B.

Scientific Development Group
E.V. Orgsnon
Oss, Holland
Dear Alan,

I have the two tapes and have put them sside until
data for you.
record
can

we

Dr. Lange's problem with subjects becoming so sleepy with
the low doses of dissepan is most interesting. In our heads, doses
up to 10 25 here been well tolerated and only rarely have we had
subjects descend into stage 3~h sleep, to be undisturbed by the
buzzer. Usually we have allowed these periods to continue to the
end of the fifth minute, when the subject is alerted by verbal
cues, with the request to open his eyes for ho seconds. If this
is unsuccessful, we have allowed another period (up to 5 minutes,
but this has occurred only ones) when verbal questions are again
tried-~ if unduecessful, the experiment was terminated and the
session repeated a week later. My staff can recall only a few
such occasions-— with dissepsn 10 mg; doxepingHCl, 25 mg; and 20
mg imiprsnine.

ours,

we

Should it prove that his subjects are more sensitive than
should investigate the phenomenon further. (What is the

ambient temperature of the room 1 How active is the air circulation
during these experiments~~ could the room he considered 'stuffy'.
encouraging sleep 2)

we

I have already cabled my willingness to use 10
have already carried out some pilot studies without

mg

amitriptyline--

difficulty.
trip is as yet

are you coming to the U.S. ? My own
Shapiro is leaving this week~end for s meeting in
when
and
we reached Jim Porsek, he indicated he would
Switzerland,
meet Don there. I am awaiting approval from HIMH for our Greek
extension before scheduling a return visit. Will write as soon as
when

unscheduled.

I

know.

,

My

Don

best regards.

Sincerely yours,
Max

Fink,

M.D.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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