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                  <text>u

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73SB~01hA
Mr. R.

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GradweIl, Contracting Officer

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January 6, 1973

Contracts Management Branch
National Institute of Mental Kealth
Rockville, Maryland 20852

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I an.vriting with regard to the equipment needs of the
contract, Antagonists 3.3 Qgiates (31-6068A) at this University. The
proposal calls for an evaluation of the efficacy of eyelasocine and
methadone in the treatment of opiate dependence. Among the criteria
are those for an adequate dose or methadone (tolerance to high doses),
and e blackening dose of cyclesocine. defined by its blockade of an
administered dose of an opiate, usually diaoetylnorphine (heroin).
The criteria for blockade are subjective reports, chooses in behavior.
respiratory rate, papillary size, and EEG. While no single criterion
is essential, none alone are satisfactory, for expectation and set are
important aepects of an addict's response to an injection.
_

In the negotiations in June, we indicated that some equipment
for the study program would be avialable, including an EEG, but not the
tape recorder necessary to provide the interface between the EEG and
the computer analytic facility at the university. Nor are we able to
provide the equipment for pupillonetry.
Should objective measures for the effects or eyelasoeine be
pupilloneter and a tape recorder should be
provided. Should subJeetive criteria be sufficient for the evaluations,
these requests thould be denied.
deemed important, both a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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Dear Mr. Gradwell,

cc: Alon Ramsay, M.D.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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