http://exhibits.library.stonybrook.edu/mfp/files/original/725826608e7b2077a74bdfb778ffd07c.pdf 8dfeb822698b2811f0b54c302a841c3f PDF Text Text 'r 94.2.; ’ December 5, 1972 Jonathan 0. Cole, Superintendent M.D. The Commonwealth of Massachusetts Department of Mental Health boston State Hospital soston, massachusetts 02124 Dear Jon; I read the ”Effects of Acute Administration of Papaverine the EEG and Behavior of the Normal Geriatric” with interest. findings are consistent with the prevailing hypotheses relating change and behavior. dCL on The LEG The discussion focusaes on the issues that I would raise: the selection of subjects and the drug dosage. The study should be continued in elderly subjects with EEG evidence of decompensation. Ihe dosage issue is also critical, and a dose finding study would be useful, using progressively higher doses in pairs of subjects until EEG evidence of change is clearly evident or behavioral tox— icity limits further trials. (Now that our EEG profiling methods, the recording and analyses, are standardized, the dose finding has become the most difficult part of our studies). text leaves a battery of significant time Span. When are the behavioral tests done, in relation to the EEG, and in relation tests is The few questions unanswered. large and must occupy a to the drug ingestion? How long an EEG sample The is taken? The hypothesis anticipates a change in mean alpha frequency, abundance (amount). It is possible for the amount of 8~9 cps not be reduced, and 10-11 cps to increase, and yet, the total alpha to not exhibit much change. Indeed, this is not infrequent ~ we have reported this type of change with cannabis, and others have noted similar effects in cats with psychotropic drugs. It may be appro« priate to undertake a ”narrow band” analysis, i;g., reanalyze the records filtering first so that activity below 5 cps and above 13 (15) ops is suppressed, and then measure the changes in l—cycle band widths from 6 to 13 cps: �'T December 5, 1972 Jonathan 0. Cole, M.D. were unaffected, it is conchanges minimal. The task remains, to define the central effects of papaverine, and both dosage, time, and sub— jects may have to be varied to achieve the result, or to state that Finally, since behavioral tasks sistent to find the CNS EEG effects are not significant. George Gardos has sent us a restatement of the times and dosages of the subjects in the thiothixene study, requesting a reanalysis. We will rerun the analyses as soon as I am able the equipment is moving this week and it may be some time until we are — able to get to this work. I look forward to seeing you in San Juan. Sincerely yours, Max Fink, M.D. Professor of Psydhiatry iF:gg � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Cole, Jonathan O. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-026-6-458 Date A point or period of time associated with an event in the lifecycle of the resource 1972 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence