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                  <text>December 19th. 19??

Dr. William Martin,

Director, ﬁational Institute for

Mbntal

Health Aadiction Research Center,
aexington, Kentucky.
Dear
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mpavaah'mrwmzwz:

1-,“:

oﬁn’;

Bill,

'Last year I was invitad £0 lectura in Europe on
aur experiencea with the narcotic antagonists. After
I had indicated the need far longer lasting ana pure
narcotic antagonists, the vicenprasiﬁent 0t M.V. Organon
sent ma the analoseﬁ memorandum on a compound

n—cyclepropylmethylnoroxycoﬁone hydrdbromide (0130).
After raading thia documant I was imyresaed that the
compound

warranted further atuay. In seeking the

as

(3138050) and was presented

aubmissiona
UMkT3

The

the

I

found

presentation
compound

I

is

13

that this

campound had been

in the

HBO

tented

196k meeting.

ﬁnadequate, but the data suggests

long noting and an antagonist.

to advisa them
along the proper steps to ba takan to furthar develop

this

havn bean asked by H.V. Organon

compound.

gm,

w

,‘II'I'I-t‘

"m:

:-.-g=,-,-s-gpvw:qnmw

1»),-

Wm?

Ordinarily. I would havu hesitated procaeding further,
but 1n‘raading your report on naitrexone I have become

that this aanpound may alsa exhibit some of the
nannistia features which hays tended ta discredit

anxious

cycluaoeine.

I vauld appreeiaze

your sdvica as ta whether 0130
warrant: turthar investigntion. All the awaildblc data
is in the enclosed manorandum. Further study would
raquire animal toxicology similar to thong undertaken for
diprcnorphine and it ”clean" furtbgr human touting.
unfbrtunately H.V. Organon does not hold the patent for this
formulation gnd tharefbre, their principal interest is in
contributing to our information. I believu they vauld
make the cumpound awnilable and vould cooperate to the
artent practicable should.vn encourage it.

�Dr. William martin

I

~2—

December 19kt. 1972

would ask that you keep the information confidential
until I have had an opportunity to discuss
with you.
I would bo grateful if you would take the time to advise
us. for I know of no—one else whose View of the narcotic

it

antagonists in so clear.

year.

my

very best wishes for a auocosnful and happy
Sincerely yours,

Mo: Fink, M.D.
Professor of Psychiatry

MF/ 1;;

new

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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