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                  <text>November

2,

1972

Elmer A. Gardner, K. .

Birector

Department of ﬁenlth, Education,

and welfare
Public Health Servico
Food and Drug Administration
Rookvillo, Maryland 20852
Door A1:

Encloaed is a preliminary report of our atudios of high
dose oyclazocine. This report summarizes the data as of
September 14, 1972.

to

24

Sines than,

.3. daily.

we

have incroaaed dosages

in three patients

We wish to award our protocol to indicnco that we will
increase daily doomgos to 33 mg. and assess rho tolerance to this
deco, coo tho duration of antagonism to 25 mg. horoin at 48, 72,
96, and 120 hours.

Sooniok.

The work

continues undo: the direct supervision of Richard
Sincoroly yours,
Pink, Hobo
Professor of Psychiatry

1‘18!

£3213

inc.
cc:

9.. Ran-nick

A.

I.

Prooooan

�</text>
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