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                  <text>Rovember 8, 1972

Dr. Gordon

Jueter

ReurOpeychiatric Evaluation Unit
Yale~ﬁew Keven Hospital

inertial

New

Unit - 10 Heat
Haven. Connecticut 06504

Dear Dr.

Jester:

the request of
experiences with him.
At

Mr. Joseph

Reylor,

VG

are

amusing

our

volunteered for e series of experiments in which subjects
receive, at weekly intervele, single orel dose: of psychoactive druge.
The dosages are selected as "threshold" ~ the minimum
necessary to
He

elicit behavioral or

verbal behavior.

EEG,

physiOIOgic

heart rate,

effects.

The

and mental

recording includes

status. Volunteers are

males, over 21 years of age, with e history of drug use (usually cannebis and hellucinogens).
goal of the study ie to define the
correletione of psychoactive drugs.
The

Mr. Baylor

have n normal EEG.
dicated no symptoee
He

EEG

and beheviorel

volunteered on April 12. 1971 end wee found to
A screening interview we: unremarkable; he
inor treatment suggestive of mental illness.

bed an adaptation experiment in which he received e plecebo.

On April 22, May 6. May 13, end May 20. 1971 he received
four coepounde; dieeepee 10 mg., placebo end two new beneodieeepenes
related to diexepem. During each session, ﬁnd in the poet eeseion
period ee reported the next day, be exhibited the usual symptoms of
mild sedation. From the self reports, it was not possible to separate
active drugs from placebo, although the EEG recordings were distinguishable.

�Dr. Gordon

Jueter

Hovember 8. 1972

efter the last session, he called to say
reported thet he had been involved in an
accident a day after the third EEG aaaaion. and insisted on knowing
the nature of the drug given. The cane information described before
the experiment was described again, and he was told that the sessions
included placebo. A physician we: not available the day he visited,
and he was asked to return the next day; but he did not.
Sir

he did not

weaka (7/9/71)

feel well.

He

On July 31. 1972 (after one year) he came spontaneously to
the study unit and was seen by a physician, who noted that Mr. Raylor
complained of headaches, intolerance of heat. feeling dazed, meleiSe
and trouble with concentration. Also he reported "electrical static
sounds from inside my head". The physician found him anxious, eoee~
what diahevelled. and perueveriug about the question of drug: causing

his symptona.
Be

inaiated again on knowing more about the drugs given him,
told about the general nature of the compounds, their

and again he was

sedative qualities, egg.

he did not seem

to accept this reassurance.

The new compounds used in the study were given to 23 subjects,
without untoward affect, and have since been identified an diaaepee-like.
undergoing clinical trials as oedetiva—anxiolytica.

I trust these data are useful.
Sincerely yours.
Fink, 3.9.
Praia-cor of Paychiatry

Mex

MF:ig

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              <text>Correspondence to: Juster, Gordon</text>
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              <text>1972 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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