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                  <text>‘2.»

d

Louis

Gottschalk,

A.

November

9,

1972

M.D.

Professor and Chairman
University of California

Orange County Medical Center
101 South Manchester Avenue
Orange, California 92668

Dear Lou:

Enclosed are copies of the
proposal for an examination of the

RPR
EEG

and a more detailed study
and blood levels of butaper-

azine. The study did not get off the ground, principally because
the investigator suddenly left the V.A., and I have not replaced him.
Recently I wrote a summary of some of our EEG studies from
the point of View of bio~availability, and enclose a copy.

The subject of blood and brain levels for drugs in intriguing.
One would anticipate good correlations, but for many drugs, a blood~
brain barrier seems to operate, or, the CNS effects seem to exhibit

step functions, as with lithium and cycloserine.

I hope that you will find some way to measure the
as carefully and as reliably as the blood measures!
Good

luck, and

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:ig
Enc.

Bioavailability
Cycloserine

RPRrButaperazine

EEG

changes

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