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                  <text>Q

ﬂavonbor 15. 1972

Samuel. c. Kain, em).
Coordinator, VA—SAODAP
Steering Connittoc
Veterans Adniuiatrution
Bepartmont of ﬁndicios Ind Surgery

Hashington, 9.0.

ZQéZO

Dear Sam:
The preposal for a cooperative study evaluating the usa of
narcotic antagonists in withdrawal of addicts from nothadona maintenance is interesting. I have a tow questiona which may olucidatc

the proposal.

1. The record does not indicate the basic for the choice
of domepin as an antidepressant, rather than imipracinc.
2.

Why

are sufficient?

elect s

21 day

induction to cyclasocino

whoa 4 days

3. Why scloct 6 mg/day no the done of cyclazocino, if antidepressant activity is to be tested, whom the antidepressant activity
of cyclazocino has baen demonstrated at 1 1/2 to 2 1/2 mg/day in
dopressiv: patienta? Or, is part of the tout a comparison of nor—
cotic antagonist activity of cyclarocino with doxopin‘s antianxiety

activity?

Jeff: and Sonny (pages 3~A) suggests they
and phanothicxines in small doses,
antidopressanto
tricyclic
useful. By what criteria? The can: quostioua are raised for the
data of Kline and Pfizer (page 5).
found

A.

Raferoncs to

5. 1a a ton sock withdrawal from mothadona fcoaiblo? Would
such a slow withdrawal allow a high rate of racidivism? Perhaps, a
more rapid detoxification, at 5 og/day for 10~20 days would be foa-

.ibha

�J”

-\-‘:‘
,

Hovombor 16. 1972

Sonuol C. Kola, M.D.

Barman

6.

For adverse

rotations, the protocol auggasto roaching
is unoful only during busi-

or myself.
I ouggoot 516-‘i4-2413 or

noos hours:

The Stony Brook phone

516-466-5444 evenings and vookondo.
Hy

2&amp;6?

during businooo; and

boot Vishnu.

Sincoroly yours,
ﬂax Fink, H.D.

Professor of Poychiatry

ﬁing

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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