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                  <text>Samuel Kain, M.D.

Coordinator,

VA—SAODAP

Veterans Administration
Washington, D.C. 20420

September 15, 1972

Steering Committee

Dear Sam,

‘I have read the protocol of the levomethadyl vs. methadone
cooperative study. The design is satisfactory, and the forms servicable.
Some

suggestions:

Side effects check-list: What is # 12 ?
Attachment C: Who fills this out, and is it to be verified
Attachment D: Is this to be verified ? By whom ?

?

References: For f 8, see attached. You may also wish to
summary of the study of the duration of methadone's cross tolerance
may be relevant to the issues of the study (Reprint enclosed).

include a

for

it

We are completing the study of increasing dosages of
levomethedyl, and the data at present indicate that 50 mg LAAM provides
blockade to 25 mg heroin for 1! hours. but at this dose of LAAM, there
are subjective complaints of discomfort. To suppress discomfort and to

maintain pupillary miosis for
The
My

72

hours,

report will he sent to
best regards.

80 mg

LAAM

is required.

you as soon as

it is

completed.

Sincerely yours,
Max

Fink, ..D.

Professor of Psychiatry

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