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                  <text>August 22, 1972
Dr. Jerome H.
SAODAP

Jaffe

The White House

Re; Diprenorphine (M-SOSO)

Washington, D.C.
Dear Dr.

Jaffe,

you know, we have undertaken the pharmacologic testing
of diprenorphine (M—SOSO) to comply with the interpreted regulations
of the FDA, to permit us to assess the clinical pharmacology of this
compound in opiate dependence. We have had some difficulty in obtaining supplies of diprenorphine sufficient for these toxicology studies,
but did receive, this week, 15 grams from Reckitt &amp; Colman-- sufficient
to complete the animal trials.
As

if the

These
compound

trials will be completed by the end
is 'safe', we will apply for an IND,

to undertake the clinical studies in February, 1973.

of the year, and
and should be ready

have been advised by Dr. G. Blane of Reckitt &amp; Colman
that future supplies will have to be obtained from Lederle Laboratories.
When we attempted to obtain some supplies from Lederle in May/June, we
were told that they were disinterested in such studies.
We

believe that the assessment of diprenorphine for opiate
health possibilities. Anticipating difficulty
in obtaining supplies in 1973, I am writing at this time to ask your
assistance and advice as to the best procedure we may follow, to
assure an initial supply of 15 grams for human studies. The availabilitt
of a supply of M-SOSO in February, 1973 will permit us to fulfill one
of the committments of the NIMH contract 42-72~207.
We

,3..-

w,

,.

arr

”my-n.-

dependence has public

Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Ramsay,

NIMH

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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