http://exhibits.library.stonybrook.edu/mfp/files/original/d1a158b774a918b8349a35f0477d3be7.pdf 86aba34b4ba04b0fdc65f89629fe7569 PDF Text Text Jun. 7, Jean Paul Smith and Alisa Runs To: 1972 , national Institute of Hental gtzicn 5600 Fishers Lane Rockvilla, Maryland 20852 flax Fink, fi.D. PROM; SUBJEDv4 4 Drug Use: harcotic Addiction Program During 1972-73, the SUNY~Stony Broot Drug Abusa ptogram.will examine tha usefulness of cyclazocinc in their treatment of opiate to methadone and leVumethadyl. In this dependence, and compare study. diacetylmorphine will be used in “heroin h lleuges” to mea— sure tha degrea-of blockade (to éefine adequacy, duration) and to demonstrate the potency of these substances as a 3tep in the decon* it . ditianing process. (1) nglggggigg. After detoxification, patianta will be 1ndt¢tod to h—6 mg. cyclazocine in 4~6 days. As an antagonist to the agent-tic features of cyclaxocine, naloxone hydrochloride (0:31) 600 mg. q3h; prr.n. will be availabln for the 4»6 days of the in— duction period. �Jean Paul Smith 8 Allan 2 June 7, 1972 Romany Following the ptovailing high dose roginono, on will induct patients in 20—40 days to 100 mg. oral daily. (Should it peeve hooful, we may adfpt a low dose (50 mg/dly] schedule). (2) Mothodono. 0 Induction to 80 n3. thrac in plannod.vith tho induction poriod of 6 weeks. (3) v. will Levomothadz . tin“ a week (b) Heroin Chgllongo . Following our doocribod nethoda, use intravonouo heroin (20,30 ng/lcc onlino/luiinutc) when subjects at. drug-fro. (to dotino heroin response) and whom induction to cyclnxocinc, levooethadyl, or nothodoln 13 achiavod, to define efficacy and duration of blockade, and b» {novide a basis for do— conditioning. mueafifiefiem Based on 50 patients receiving cyclazociné, and 45 each on methadone and levomethadyl. 6: 90 liters, Cyclazocine: 36 Naloxonofi 240 grams (800 Methadone: 500 grams (powder) Levomethadyl: 150 grams (powder) Heroin; 10 grams grams tablets, (powder) 2 mg/Scc) 300 mg each) / �Joan Paul Smith & 3 _ Allen Ramsay Juno 7. 1972 CITAIIOHS Haloxonn Paloata: A Long~Act1n3 Opiate Antlgoniut, (submitted for publication). (R. Lavina, A. 23kt. I, A. Frudlun). Luvoanthadyl 1n Haintenanco Trcatncut of Opiatc Dopendcnna. (A. Zaka, f, A. Froodnnn). Duration of Hathadon. Induced Crocc~Toleranca to attain. Addict. 66: zoswzos. (A. 2m, 9. A. M. Kama-nu). 84. J.A.%.A., '“ I J. Cyclaxocina Therapy of Opiate Uepcndcnca w & Progress Report. Compachenb. Psych£a£., 12: 491‘502, (R. Rasnick, 3, and A. M. Freedman). A Rational Therapy of Opiate Dependence: Amen. and R. J. NuAéLug, 71: Maniac) . 1359-1363. Harcotic Antagonists. (with A. H. Frocdmsn, A. inks, Naloxone Traatment of Opiate Dependence. (A. Zaks, T. Jonas, A. fl. Fraedmnn) 5). J.A.M.A., 215: 2108*2110. Cyclarocins Typology in Opiate Dependence. Amen. J. 7&ychiat., 1256-1260. (B. fiesnick, # and A. H. Freedman). 126: Intravenous Qiacetylmorphina (Heroin) in Studies of Opiate Dependauco. Ned». Syét. Supp£., 33: 89~92, 1969. (A. Zaka, A. Brunet, 5. die. A. Freedman). aaloxone in heroin Depcndence, C££n. Phanm. Thenap., 9: 568~577. (with A. Zaks, R. Sharoff, A. Mora, A. Brunet, S. Levi: and A. H. Freedman). Clintcal Studies of Cyclazocine in Narcot1c Addiction. AmeA. J. P3gchiat., 124: 1499~1504. (A. a. Frcedman, #. fi. Sharoff, and A. Zikl). V/ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Smith, Jean Paul and Ramsay, Allen Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-026-2-174 Date A point or period of time associated with an event in the lifecycle of the resource 1972 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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