http://exhibits.library.stonybrook.edu/mfp/files/original/0f6e894db600b02aff3708e936b4559e.pdf a32d442be5e3d59a29f4839e1e40293b PDF Text Text w." WWM', June 7, 1972 Mr. John A. Hamilton New New York Times York City Dear Mr. Hamilton, 1 I very much appreciated your balanced presentation of the problems inherent in a heroin delivery research project in your article, Free Fix fbr Addicts ? on June 5. In addition to the problems described by Drs. Jaffe, Dole, and Phillipson, we should add the special risks of heroin administration. In our studies at this center, we have used 'heroin challenges' as a specific index of the duration of action of narcotic antagonists. This experience has brought to our attention that intravenous heroin has effects on heart rate and the EKG; on cerebral rhythms (exciting seizure activity sufficient on at least three occasions to precipitate a grand mal convulsion); and on respiration. The sequence of events are often unpredictable, since the men vary in the degree of the induced cross-tolerance to opiates they have developed. Even in the laboratory, there are problems; we are not sanguine about a large scale delivery system. Indeed, rather than seeking the use of shorter acting opiates, as heroin or morphine, there is logic in seeking opiateelike with durations of activity longer than methadone. Levomethadyl, the l-alpha-acetylmethadol, is such a substance. Instead of seeking the use of a short acting substance, the leaders desiring to innovate might do well to look into the greater use of this substance: by providing a longer duration of cross~tolerance, dosages must be taken only three times a week, reducing both the problems of irregular intake and that of 'seepage' of illicit materials into the community. Levomethadyl is also taken orally, as is methadone. compounds Again, I wish to commend you heroin delivery recommendations. on a reasoned view of the Sincerely yours, Fink, M.D. Professor of psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Hamilton, John A. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-026-2-173 Date A point or period of time associated with an event in the lifecycle of the resource 1972 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence